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方案
99%
折射率
n20/D 1.489 (lit.)
沸点
214 °C (lit.)
密度
1.085 g/mL at 25 °C (lit.)
SMILES字符串
O=NN1CCCC1
InChI
1S/C4H8N2O/c7-5-6-3-1-2-4-6/h1-4H2
InChI key
WNYADZVDBIBLJJ-UHFFFAOYSA-N
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应用
1-硝基吡咯烷可用于研究致癌物和癌症。已在大鼠中检测了体内亚硝胺的代谢。1-硝基吡咯烷已用于研究鸡胚中的一氧化氮和自发收缩活动。
生化/生理作用
在小鼠中诱发肝细胞癌和肺腺瘤。形成主要导致 A：T 到 G：C 突变的 DNA 加合物。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Carc. 2
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
208.4 °F - closed cup
闪点(°C)
98 °C - closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
监管及禁止进口产品
Mingyao Wang et al.
Chemical research in toxicology, 20(4), 625-633 (2007-03-31)
N-Nitrosopyrrolidine (NPYR) is a well-established hepatocarcinogen in the rat. NPYR requires metabolic activation by cytochrome P450-catalyzed alpha-hydroxylation to express its carcinogenic activity. This produces alpha-hydroxyNPYR (2), which spontaneously ring opens to 4-oxobutanediazohydroxide (4), a highly reactive intermediate, which may itself
Keita Kanki et al.
Molecular carcinogenesis, 42(1), 9-17 (2004-10-16)
In order to cast light on carcinogen-specific molecular mechanisms underlying experimental hepatocarcinogenesis in rats, in vivo mutagenicity and mutation spectra of known genotoxic rat hepatocarcinogens N-nitrosopyrrolidine (NPYR), and 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), as well as the nongenotoxic hepatocarcinogen di(2-ethylhexyl)phthalate (DEHP) and the
Nuria Arranz et al.
Journal of applied toxicology : JAT, 26(5), 466-473 (2006-07-28)
The aim of this study was to investigate the protective effect of isothiocyanates towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay. None of the isothiocyanates (ITCs) concentrations tested in the presence or absence of formamidopyrimidine-DNA glycosylase (Fpg)
G Drabik-Markiewicz et al.
Analytica chimica acta, 657(2), 123-130 (2009-12-17)
N-nitrosamines are meant to be probable or possible carcinogenic components, possibly formed out of a reaction between nitrite and N-containing substances such as amino acids and secondary amines. Nitrite is often used for processing meat products because of its colouring
F W Krüger et al.
Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology, 83(3), 255-260 (1975-01-01)
After i. p. application of 6 mg/30 muCi/kg 2,5- and 3,4--14C-nitrosopyrrolidine about 20% of the radioactivity is exhaled as 14-CO2 and about 7% is found in the urine. One of the urinary metabolites was identified by thin layer chromatography, combined
商品
DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
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