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Merck
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主要文件

安全信息

113R-2

Sigma-Aldrich

CD13 (EP117) Rabbit Monoclonal Primary Antibody

别名:

Aminopeptidase-N

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About This Item

UNSPSC代码:
12352203

生物来源

rabbit

质量水平

100
500

偶联物

unconjugated

抗体形式

culture supernatant

抗体产品类型

primary antibodies

克隆

EP117, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions (See Chart)

表单

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (113R-24)
vial of 0.1 mL concentrate Research Use Only (113R-24-RUO)
vial of 0.5 mL concentrate (113R-25)
vial of 1.0 mL concentrate (113R-26)
vial of 1.0 mL concentrate Research Use Only (113R-26-RUO)
vial of 1.0 mL pre-dilute Research Use Only (113R-27-RUO)
vial of 1.0 mL pre-dilute ready-to-use (113R-27)
vial of 7.0 mL pre-dilute ready-to-use (113R-28)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (113R-28-RUO)

制造商/商品名称

Cell Marque™

浓度

0.1-5 μg/mL (predilute)
2.5-125 μg/mL (concentrate)

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

同位素/亚型

IgG

控制

liver

运输

wet ice

储存温度

2-8°C

可视化

cytoplasmic, membranous

基因信息

human ... ANPEP(290)

相关类别

一般描述

CD13 (aminopeptidase-N) is a transmembrane protease present in many tissues and cell types (e.g., endothelial and epithelial cells, fibroblasts, and leukocytes). CD13 is expressed in various solid and hematological malignancies in humans and is useful in identifying acute myeloid leukemia when used in a panel including antibodies against CD13(+), CD34(+), CD117(+), CD16(-), and CD33(+). This protein is also expressed in myeloid sarcoma and anti-CD13 is useful in its identification using a panel.

In addition, it has been reported that CD13 is expressed in both normal and neoplastic liver tissue, where it exhibits a canalicular distribution pattern similar to that seen for polyclonal CEA and CD10. Thus, anti-CD13 can be useful as an additional marker in differentiating between HCC and non-hepatocellular neoplasms.

质量

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

联系

CD13 Positive Control Slides, Product No. 113S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

制备说明

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

Download the latest released IFU
Note: This IFU may not apply to your specific product lot.

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

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分析证书(COA)

Lot/Batch Number
0000401988
0000401988
0000314445
0000335282
0000320823

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访问文档库

Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients.
Pileri SA, et al.
Leukemia, 21, 340-350 (2007)
Canalicular immunostaining of aminopeptidase N (CD13) as a diagnostic marker for hepatocellular carcinoma.
Rocken C, et al.
Journal of Clinical Pathology, 58, 1069-1075 (2005)
Aminopeptidase-N/CD13 is a potential proapoptotic target in human myeloid tumor cells.
Piedfer M, et al.
Faseb Journal, 25, 2831-2842 (2011)
Acute promyelocytic leukemia: four distinct patterns by flow cytometry immunophenotyping.
Gorczyca, W.
Polish Journal of Pathology : Official Journal of the Polish Society of Pathologists, 1, 8-17 (2012)
Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects.
Bauvois B, et al.
Medicinal Research Reviews, 26, 88-130 (2006)
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