08445
7-氨基-4-甲基香豆素-3-乙酸
BioReagent, suitable for fluorescence, ~90% (HPLC)
别名:
2H-1-苯并吡喃-3-乙酸, 7-氨基-4-甲基-3-香豆素醋酸, AMCA酸
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关于此项目
经验公式（希尔记法）:
C12H11NO4
化学文摘社编号:
分子量:
233.22
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
Beilstein/REAXYS Number:
7927205
InChI key
QEQDLKUMPUDNPG-UHFFFAOYSA-N
InChI
1S/C12H11NO4/c1-6-8-3-2-7(13)4-10(8)17-12(16)9(6)5-11(14)15/h2-4H,5,13H2,1H3,(H,14,15)
product line
BioReagent
assay
~90% (HPLC)
form
powder
solubility
DMF: soluble, DMSO: soluble, aqueous base: soluble
fluorescence
λex 350 nm; λem 433 nm in methanol
suitability
suitable for fluorescence
Quality Level
Application
AMCA是一种用于标记蛋白的试剂。其在345 nm处具有特征吸收峰以及在440-460 nm处具有荧光发射（蓝色区域）；然而，当与蛋白质缀合时，吸收峰移至355 nm，并在440-460 nm处发射荧光。其具有高的荧光产量和足够的斯托克斯位移（100 nm），并且相对光稳定 。其相对容易被激活并偶联至肽的N端氨基，从而形成酸稳定的酰胺键 。
Packaging
无底玻璃瓶。内含物在插入的融合锥体内。
Other Notes
有效的蓝色荧光团，可用于免疫荧光， λabs ~350 nm, λem ~440 nm
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Meera Mohan et al.
British journal of haematology, 189(1), 67-71 (2019-12-11)
Gain of chromosome 1q21 and the gene expression-based GEP70 risk score are established prognostic markers for newly diagnosed Multiple Myeloma (MM) patients. Here we addressed the prognostic impact of these two markers in 81 relapsed/refractory (RR) MM patients treated with
D Delia et al.
Cytometry, 12(6), 537-544 (1991-01-01)
Antibodies coupled to 7-aminocoumarin (AMCA) emit a bright blue fluorescence under ultraviolet (UV) excitation and are therefore ideal for three-color immunofluorescence (IF) with fluorescein (FITC) and phycoerythrin (PE) labeled reagents; however, due to the different absorption spectra, the use of
P A Muraro et al.
The Journal of clinical investigation, 100(2), 339-349 (1997-07-15)
The pathogenesis of multiple sclerosis (MS) is currently ascribed in part to a T cell-mediated process targeting myelin components. The T cell response to one candidate autoantigen, myelin basic protein (MBP), in the context of HLA-DR15Dw2, has been previously studied
B Ulfhake et al.
Journal of neuroscience methods, 40(1), 39-48 (1991-11-01)
This paper describes the implementation of an ultraviolet (UV) laser (Spectra Physics 171-18 with 3 lines: 334, 351 and 364 nm in UV) as light source for fluorescence confocal scanning microscopy. With this instrument it is possible to use fluorophores
M W Wessendorf et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 38(1), 87-94 (1990-01-01)
7-Amino-4-methylcoumarin-3-acetic acid (AMCA) has been found to be a useful fluorophore for immunofluorescence. The present study describes a spectrophotometric method for determining the ratio of moles AMCA to moles protein (or the f/p ratio) in an AMCA-conjugated IgG. The concentration
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