质量水平
检测方案
≥95% (HPLC)
组成
lithium, 5.0-14.0% ICP
杂质
≤8.0% water
储存温度
−20°C
SMILES字符串
O=C(O)C(COP(O)(O)=O)=O
InChI
1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)
InChI key
LFLUCDOSQPJJBE-UHFFFAOYSA-N
相关类别
生化/生理作用
L-丝氨酸可能有四种来源：饮食摄入、糖酵解中间体 3-磷酸甘油酸生物合成、甘氨酸以及蛋白质和磷脂降解。在生物合成途径中，在3-磷酸甘油酸脱氢酶（3-PGDH； EC 1.1.1.95）催化的反应下，糖酵解中间体3-磷酸甘油酸转化为磷酸羟基丙酮酸。磷酸羟基丙酮酸氨基转移酶（EC 2.6.1.52）将磷酸羟基丙酮酸代谢为磷酸丝氨酸，最后，磷酸丝氨酸磷酸酶（PSP； EC 3.1.3.3）将磷酸丝氨酸转化为L-丝氨酸。 在肝脏组织中，丝氨酸生物合成途径受饮食和激素变化的调节。在这三种合成酶中，以 3-PGDH 和 PSP 的属性记载最好。激素因素，如胰高血糖素和皮质类固醇也影响 3-PGDH 和 PSP 的活动的相互作用依赖于饮食。L-丝氨酸在细胞增殖中发挥核心角色。L-丝氨酸是嘌呤核苷酸和脱氧胸苷一磷酸从头合成的一碳基团的主要来源。长期以来，人们认识到，在细胞培养物中，L-丝氨酸是一种条件性必需氨基酸，因为它不能合成足够数量以满足细胞对其利用的需求。近年来，L-丝氨酸及其代谢产物被认为不仅是细胞增殖所必需的，而且是中枢神经系统特定功能所必需的。精神疾病患者丝氨酸和甘氨酸水平改变以及 L-丝氨酸合成缺陷患者的严重神经系统异常的发现强调了 L-丝氨酸在大脑发育和功能中的重要性；例如阿尔茨海默病s 病 、精神分裂症 、心力衰竭 和青少年肌阵挛性癫痫 。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Kenji Hashimoto et al.
Archives of general psychiatry, 60(6), 572-576 (2003-06-11)
The hypofunction of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors has been implicated in the pathophysiology of schizophrenia. Several lines of evidence suggest that D-serine may function as an endogenous agonist of the glycine site of the NMDA receptor. The
Sirpa Rainesalo et al.
Neurochemical research, 29(1), 319-324 (2004-03-03)
Altered plasma and cerebrospinal fluid amino acid levels may be associated with human epilepsy. We studied three groups of patients, those with a generalized epileptic syndrome, juvenile myoclonic epilepsy, patients with refractory localization-related epilepsies, and patients with acute seizures (within
H Nørrelund et al.
Journal of internal medicine, 260(1), 11-21 (2006-06-23)
It is well known that chronic heart failure (CHF) is associated with insulin resistance and cachexia, but little is known about the underlying substrate metabolism. The present study was undertaken to identify disturbances of basal glucose, lipid and protein metabolism.
K Q Do et al.
Journal of neurochemistry, 65(6), 2652-2662 (1995-12-01)
HPLC and gas chromatography-mass spectrometry analyses of 18 amino acids, N-acetylaspartate, N-acetylaspartylglutamate, and 5-hydroxyindoleacetic acid, derived from serotonin, and homovanillic acid, derived from dopamine, were performed in CSF collected from a group of patients with schizophrenia who either had been
A N Fonteh et al.
Amino acids, 32(2), 213-224 (2006-10-13)
Our aim was to determine changes in free amino acid (FAA) and dipeptide (DP) concentrations in probable Alzheimer's disease (pAD) subjects compared with control (CT) subjects using liquid chromatography and electrospray ionization tandem mass spectrometry (LCMS2). We recruited gender- and
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