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Merck
CN

01930

Sigma-Aldrich

腺苷 5'-单磷酸 二钠盐

≥99.0% (HPLC)

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别名:
5′-AMP二钠盐,, 腺苷酸二钠盐, 5′-AMP-Na2
经验公式(希尔记法):
C10H12N5Na2O7P
CAS号:
分子量:
391.18
Beilstein:
3586732
EC 号:
MDL编号:
UNSPSC代码:
41106305
eCl@ss:
32160414
PubChem化学物质编号:
NACRES:
NA.51

生物来源

microbial (Candida utilis)
synthetic

质量水平

检测方案

≥99.0% (HPLC)

形式

powder

旋光性

[α]20/D −43±2°, c = 1% in 0.5 M Na2HPO4 (dry matter)

杂质

≤26% water

SMILES字符串

[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]3O

InChI

1S/C10H14N5O7P.2Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20;;/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1

InChI key

QGXLVXZRPRRCRP-IDIVVRGQSA-L

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应用

5′-单磷酸腺苷二钠盐已用于:

  • 作为可溶性有机磷(DOP)化合物,以研究在大肠杆菌裂解物中的水解速率
  • 诱导Fura2成骨细胞(C2-OB)钙反应
  • 在分离、培养和鉴定胶质瘤干细胞(GSC)的培养基中作为核苷酸代谢物
腺苷5′-一磷酸(5′-AMP)在自然界中具有许多用途。5′-AMP是一类蛋白激酶[AMP活化蛋白激酶(AMPK)]的激活剂。它可以用作多种酶的底物,如AMP-胸苷激酶(EC 2.7.1.114)、AMP脱氨酶(EC 3.5.4.6)和5′-核苷酸酶(EC 3.1.3.5)。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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The 5'-AMP-activated protein kinase (AMPK) functions as a metabolic fuel gauge that is activated in response to environmental stressors to restore cellular energy balance. In the heart, AMPK coordinates the activation of glucose and fatty acid metabolic pathways to ensure

商品

Separation of AMP (adenosine monophosphate); ATP (adenosine triphosphate)

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