产品名称
(±)-氯胺酮 盐酸盐, European Pharmacopoeia (EP) Reference Standard
InChI
1S/C13H16ClNO.ClH/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14;/h2-3,6-7,15H,4-5,8-9H2,1H3;1H
SMILES string
Cl.CNC1(CCCCC1=O)c2ccccc2Cl
InChI key
VCMGMSHEPQENPE-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
ketamine
manufacturer/tradename
EDQM
drug control
regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Gene Information
human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444)
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Application
Ketamine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral - STOT SE 3
target_organs
Central nervous system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
Paulo R Shiroma et al.
The international journal of neuropsychopharmacology, 17(11), 1805-1813 (2014-06-26)
The N-methyl-D-aspartate glutamate receptor antagonist ketamine has demonstrated rapid antidepressant effects in treatment-resistant depression (TRD). However, evaluation of ketamine's neurocognitive aspects in TRD has started to be explored. This study aims to (1) examine baseline neurocognitive performance and change in
Yongzhi Wang et al.
American journal of physiology. Heart and circulatory physiology, 308(5), H540-H547 (2014-12-17)
Abdominal sepsis is associated with significant changes in systemic inflammation and coagulation. The purpose of the present study was to examine the role of peripheral blood monocytes for systemic coagulation, including thrombin generation and consumption of coagulation factors. Abdominal sepsis
Jana Sawynok
Anesthesia and analgesia, 119(1), 170-178 (2014-06-20)
Ketamine, in subanesthetic doses, produces systemic analgesia in chronic pain settings, an action largely attributed to block of N-methyl-D-aspartate receptors in the spinal cord and inhibition of central sensitization processes. N-methyl-D-aspartate receptors also are located peripherally on sensory afferent nerve
Yongzhi Wang et al.
Shock (Augusta, Ga.), 42(4), 343-349 (2014-07-01)
Systemic inflammatory response syndrome and severe infections are associated with major derangements in the coagulation system. The purpose of this study was to examine the dynamic alterations in thrombin generation in abdominal sepsis. Abdominal sepsis was induced by cecal ligation
José Luis Calvo-Guirado et al.
Clinical oral investigations, 18(5), 1495-1505 (2013-10-19)
This study presents a biomechanical comparison of bone response to commercially pure titanium screws with four different types of surface topographies placed in the tibial metaphysis of 30 rabbits. One hundred twenty implants were tested double-blinded: (a) blasted, acid-etched, and
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