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Merck
CN

Y0000218

昂丹司琼 盐酸盐 二水合物

European Pharmacopoeia (EP) Reference Standard

别名:

1,2,3,9-四氢-9-甲基-3-[(2-甲基-1H-咪唑-1-基)甲基] -4H-咔唑-4-酮 盐酸盐, GR 38032F

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关于此项目

经验公式(希尔记法):
C18H19N3O · HCl · 2H2O
化学文摘社编号:
分子量:
365.85
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
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产品名称

昂丹司琼 盐酸盐 二水合物, European Pharmacopoeia (EP) Reference Standard

InChI key

VRSLTNZJOUZKLX-UHFFFAOYSA-N

SMILES string

Cl[H].[H]O[H].[H]O[H].Cc1nccn1CC2CCc3c(C2=O)c4ccccc4n3C

InChI

1S/C18H19N3O.ClH.2H2O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;;;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H;2*1H2

grade

pharmaceutical primary standard

API family

ondansetron

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Gene Information

human ... HTR3A(3359)

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Biochem/physiol Actions

5-HT3 血清素受体拮抗剂

Application

Ondansetron hydrochloride dihydrate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Ioannis Goutos
Journal of burn care & research : official publication of the American Burn Association, 34(1), 82-93 (2012-11-09)
Pruritus in burn wounds is a common symptom affecting patient rehabilitation. Over the last decades, there has been a resurgence of interest into more effective strategies to combat this distressing problem; nevertheless, no reports exist in the literature to propose
Daniel R Gomez et al.
Cancer, 119(7), 1428-1436 (2012-12-06)
Nausea and vomiting (N/V) during chemotherapy can have profound clinical and economic consequences. Effective antiemetic agents are available for prophylaxis, but barriers may prevent their use. For this population-based study, the authors assessed the rates of antiemetic prophylaxis use, and
Kristi L Kinder et al.
Pediatric emergency care, 28(11), 1203-1205 (2012-11-02)
The objective of this study was to determine if overweight children are more likely than normal-weight children to require ondansetron when undergoing ketamine sedation in a pediatric emergency department. Patients between the ages of 2 and 18 years with an
Björn Pasternak et al.
The New England journal of medicine, 368(9), 814-823 (2013-03-01)
Ondansetron is frequently used to treat nausea and vomiting during pregnancy, but the safety of this drug for the fetus has not been well studied. We investigated the risk of adverse fetal outcomes associated with ondansetron administered during pregnancy. From
Ali Mujtaba et al.
Drug testing and analysis, 5(2), 122-125 (2013-02-16)
A new, simple, rapid, accurate and precise high performance thin layer chromatography (HPTLC) method has been developed for the estimation of ondansetron hydrochloride in bulk and sublingual tablets. The mobile phase composition was chloroform : ethyl acetate : methanol :

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