T0781
3,5,5-三甲基噁唑烷-2,4-二酮
analytical standard
别名:
三甲双酮
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关于此项目
经验公式（希尔记法）:
C6H9NO3
化学文摘社编号:
分子量:
143.14
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
204-845-8
MDL number:
InChI key
IRYJRGCIQBGHIV-UHFFFAOYSA-N
InChI
1S/C6H9NO3/c1-6(2)4(8)7(3)5(9)10-6/h1-3H3
SMILES string
CN1C(=O)OC(C)(C)C1=O
grade
analytical standard
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
Quality Level
Gene Information
human ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Matthew E Barton et al.
European journal of pharmacology, 521(1-3), 79-85 (2005-09-21)
The purpose of the present study was to explore the analgesic effects of the low voltage-activated T-type Ca2+ channel blockers ethosuximide, trimethadione, and mibefradil in persistent and acute nociceptive tests. The anticonvulsant effects of the compounds were also determined in
James J Collins et al.
Experimental gerontology, 41(10), 1032-1039 (2006-07-29)
The identification and analysis of compounds that delay aging and extend lifespan is an important aspect of gerontology research; these studies can test theories of aging, lead to the discovery of endogenous systems that influence aging, and establish the foundation
E Tanaka et al.
Journal of clinical pharmacy and therapeutics, 28(6), 493-496 (2003-12-04)
Trimethadione (TMO), an antiepileptic drug, may be used as a candidate for estimating hepatic drug-oxidizing activity. While TMO metabolism is mainly catalysed by CYP2C9, CYP2E1 and CYP3A4 the contribution of the different isoforms is unclear. In this study, we determined
N Kurata et al.
Xenobiotica; the fate of foreign compounds in biological systems, 28(11), 1041-1047 (1999-01-08)
1. Caucasian liver samples were used in this study. N-demethylation of trimethadione (TMO) to dimethadione (DMO) was monitored in the presence of chemical inhibitors of CYPs, such as fluconazole, quinidine, dimethyl-nitrosamine, acetaminophen, phenacetin, chlorzoxazone and mephenytoin. Trimethadione N-demethylation was selectively
Tammye L Fleeman et al.
Birth defects research. Part B, Developmental and reproductive toxicology, 71(3), 185-190 (2004-07-30)
Congenital membranous ventricular septal defects (VSD) have been shown to close during postnatal development in rats [Solomon et al., Teratology 55:185-194, 1997]. Although they may differ in size, spontaneous and treatment-related VSD are histologically similar; however, the postnatal fate of
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