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质量水平
检测方案
98-102%
形式
solid
旋光性
[α]20/D -30 to -28° in water
颜色
off-white to light yellow
储存温度
2-8°C
InChI
1S/C12H14N2O3/c1-17-8-2-3-11-9(5-8)7(6-14-11)4-10(13)12(15)16/h2-3,5-6,10,14H,4,13H2,1H3,(H,15,16)/t10-/m0/s1
InChI key
KVNPSKDDJARYKK-JTQLQIEISA-N
一般描述
5-甲氧基-L-色氨酸是一种 L-色氨酸代谢物，具有抗炎和抗肿瘤活性。5-甲氧基-L-色氨酸由色氨酸羟化酶（TPH）和羟基吲哚 O-甲基转移酶 （HIOMT）合成。5-甲氧基-L-色氨酸是一种 L-色氨酸代谢物，具有抗炎和抗肿瘤活性。其水平在疾病期间降低， 5-甲氧基色氨酸治疗可改善 CKD 小鼠模型的肾纤维化。5-甲氧基色氨酸似乎可在单侧输尿管梗阻小鼠模型中抑制IκB/NFκB信号传导并增强 Keap1/Nrf2 信号传导。
应用
5-甲氧基-L-色氨酸可用于细胞生物学、生物化学和代谢组学研究。
特点和优势
- 可用于代谢组学和生物化学研究
- 用于多种研究应用的优质化合物
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Hua-Ling Chen et al.
The Journal of biological chemistry, 293(28), 11131-11142 (2018-05-26)
5-Methoxytryptophan (5-MTP) is a tryptophan metabolite with recently discovered anti-inflammatory and tumor-suppressing activities. Its synthesis is catalyzed by a hydroxyindole O-methyltransferase (HIOMT)-like enzyme. However, the exact identity of this HIOMT in human cells remains unclear. Human HIOMT exists in several
Huei-Hsuan Cheng et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(33), 13231-13236 (2012-08-02)
Cyclooxygenase-2 (COX-2) expression is induced by mitogenic and proinflammatory factors. Its overexpression plays a causal role in inflammation and tumorigenesis. COX-2 expression is tightly regulated, but the mechanisms are largely unclear. Here we show the control of COX-2 expression by
Dan-Qian Chen et al.
Nature communications, 10(1), 1476-1476 (2019-04-02)
Early detection and accurate monitoring of chronic kidney disease (CKD) could improve care and retard progression to end-stage renal disease. Here, using untargeted metabolomics in 2155 participants including patients with stage 1-5 CKD and healthy controls, we identify five metabolites
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