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Merck
CN

PHR1796

亚胺培南

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

亚胺培南 一水合物, Primaxin 一水合物, Tienam 一水合物, （5R，6S）-6-[（（1R）-1-羟基乙基] -3-[[2-[（亚氨基甲基）氨基]乙基]硫代] -7-氧代-1-氮杂双环[3.2.0] hept-2 -烯-2-羧酸 一水合物

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关于此项目

经验公式（希尔记法）:
C12H17N3O4S · H2O
化学文摘社编号:
74431-23-5
分子量:
317.36
NACRES:
NA.24
PubChem Substance ID:
329823620
UNSPSC Code:
41116107
EC Number:
264-734-5
MDL number:
MFCD09753321

主要文件

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产品名称

亚胺培南, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

GSOSVVULSKVSLQ-JJVRHELESA-N

InChI

1S/C12H17N3O4S.H2O/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17;/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19);1H2/t6-,7-,9-;/m1./s1

SMILES string

O.C[C@@H](O)[C@@H]1[C@H]2CC(SCCNC=N)=C(N2C1=O)C(O)=O

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. I0090000
traceable to USP 1337809

API family

imipenem

form

solid

CofA

current certificate can be downloaded

packaging

pkg of 200 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

storage temp.

-10 to -25°C

Quality Level

300

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相关类别

Application

亚胺培南可作为药物参考标准品，通过各种分析技术测定生物样本和药物制剂中的分析物。

Biochem/physiol Actions

亚胺培南一水合物是广谱 B -内酰胺抗生素。
亚胺培南一水合物是广谱 B -内酰胺抗生素。 它是碳青霉烯类“魔弹”抗生素的一种，用于严重感染。

General description

药物二级标准品CRM，为制药行业QC实验室及生产质量控制和研发，提供了一种方便、高性价比且符合相关法规的替代方案。亚胺培南(imipenem)属于碳青霉烯类物质，是一种β-内酰胺类抗生素，对需氧和厌氧菌具有抗菌作用。碳青霉烯(Carbapenem)抑制细菌细胞壁形成中的肽聚糖合成，从而导致目标菌的死亡。

Other Notes

欲查看此物质的分析证书样本，请在下面的对话框中输入 LRAC0262。这只是一个示例证书，可能与您收到的批次不符。
该认证参考物质（CRM）根据ISO 17034 和 ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在分析证书上找到。

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Maria J Pons et al.
Microorganisms, 8(9) (2020-09-17)
The aim of this study was to characterize carbapenem-resistant Klebsiella pneumoniae (CR-Kp) isolates recovered from adults and children with severe bacteremia in a Peruvian Hospital in June 2018. Antimicrobial susceptibility was determined by disc/gradient diffusion and broth microdilution when necessary.
Mahjabeen Khan et al.
Antibiotics (Basel, Switzerland), 9(9) (2020-09-18)
This study investigated genomic differences in Australian and Indian Pseudomonas aeruginosa isolates from keratitis (infection of the cornea). Overall, the Indian isolates were resistant to more antibiotics, with some of those isolates being multi-drug resistant. Acquired genes were related to
Daniela Scribano et al.
International journal of molecular sciences, 20(14) (2019-07-25)
Carbapenem-resistant Acinetobacter baumannii strains cause life-threatening infections due to the lack of therapeutic options. Although the main mechanisms underlying antibiotic-resistance have been extensively studied, the general response to maintain bacterial viability under antibiotic exposure deserves to be fully investigated. Since
Zainab Edoo et al.
Scientific reports, 7(1), 9136-9136 (2017-08-24)
β-lactam antibiotics act as suicide substrates of transpeptidases responsible for the last cross-linking step of peptidoglycan synthesis in the bacterial cell wall. Nucleophilic attack of the β-lactam carbonyl by the catalytic residue (Ser or Cys) of transpeptidases results in the
Determination of imipenem in plasma by high-performance liquid chromatography for pharmacokinetic studies in patients
Garcia-Capdevila L, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 692(1), 127- 132 (1997)
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