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Merck
CN

PHR1588

吡罗昔康

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

吡罗昔康, 2-甲基-4-羟基-N-(2-吡啶基)-2H-1,2-苯并噻嗪-3-甲酰胺-1,1-二氧化物

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关于此项目

经验公式（希尔记法）:
C15H13N3O4S
化学文摘社编号:
36322-90-4
分子量:
331.35
NACRES:
NA.24
PubChem Substance ID:
329823494
UNSPSC Code:
41116107
EC Number:
252-974-3
MDL number:
MFCD00057317

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产品名称

吡罗昔康, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

QYSPLQLAKJAUJT-UHFFFAOYSA-N

InChI

1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20)

SMILES string

CN1C(C(=O)Nc2ccccn2)=C(O)c3ccccc3S1(=O)=O

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. P2130000
traceable to USP 1544508

API family

piroxicam

CofA

current certificate can be downloaded

packaging

pkg of 200 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

Gene Information

human ... PTGS1(5742), PTGS2(5743)

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相关类别

Biochem/physiol Actions

环加氧酶抑制剂。

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Piroxicam may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and urine by spectrophotometry.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Piroxicam belongs to the class of acidic, non-steroid anti-inflammatory (NSAI) drugs, with a long half-life which enables it to be administered once daily.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA4573 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

hcodes

H301,H373

Hazard Classifications

Acute Tox. 3 Oral - STOT RE 2 Oral

target_organs

Gastrointestinal tract

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Spectrophotometric determination of piroxicam and tenoxicam in pharmaceutical formulations using alizarin.
Amin AS
Journal of Pharmaceutical and Biomedical Analysis, 29(4), 729-736 (2002)
Sensitive spectrophotometric methods for the determination of amoxycillin, ciprofloxacin and piroxicam in pure and pharmaceutical formulations.
Nagaralli BS, et al.
Journal of Pharmaceutical and Biomedical Analysis, 29(5), 859-864 (2002)
Anal. Profiles Drug Subst., 15, 509-531 (1986)
A simple spectrofluorimetric method for determination of piroxicam and propranolol in pharmaceutical preparations.
Tabrizi AB
Journal of food and drug analysis, 15(3) (2007)
Determination of piroxicam in pharmaceutical formulations and urine samples using europium-sensitized luminescence.
Al-Kindy SMZ, et al.
Journal of Luminescence, 127(2), 291-296 (2007)

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