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安全信息

PHR1325

Supelco

土霉素盐酸盐 盐酸盐

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

Oxytetracycline hydrochloride, 5-Hydroxytetracycline hydrochloride

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About This Item

经验公式（希尔记法）:
C22H24N2O9 · HCl
CAS号:
2058-46-0
分子量:
496.89
Beilstein:
3853107
EC 号:
218-161-2
MDL编号:
MFCD00135815
UNSPSC代码:
41116107
PubChem化学物质编号:
329823310
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 275
traceable to Ph. Eur. O0500000
traceable to USP 1491015

API类

oxytetracycline

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

-10 to -25°C

SMILES字符串

Cl.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O

InChI

1S/C22H24N2O9.ClH/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31);1H/t12-,13-,14+,17+,21-,22+;/m1./s1

InChI key

UBDNTYUBJLXUNN-IFLJXUKPSA-N

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一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Oxytetracycline is a broad-spectrum antibiotic drug widely employed in veterinary applications, particularly for the management of infections in pig productions. It acts by inhibiting the protein synthesis in gram-positive and gram-negative bacteria.

应用

Oxytetracycline may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA0828 in the slot below. This is an example certificate only and may not be the lot that you receive.

相关产品

产品编号
说明
价格

1491015

土霉素盐酸盐 盐酸盐, United States Pharmacopeia (USP) Reference Standard

1491004

土霉素, United States Pharmacopeia (USP) Reference Standard

O0500000

土霉素盐酸盐 盐酸盐, European Pharmacopoeia (EP) Reference Standard

PHR1537

土霉素, Pharmaceutical Secondary Standard; Certified Reference Material

BP782

土霉素盐酸盐, British Pharmacopoeia (BP) Reference Standard

BP275

土霉素盐酸盐 盐酸盐, British Pharmacopoeia (BP) Reference Standard

Y0002136

系统适用性试验A用氧四环素, European Pharmacopoeia (EP) Reference Standard

PHR8912

alpha-Apo-oxytetracycline, certified reference material, pharmaceutical secondary standard

PHR8913

beta-Apo-oxytetracycline, certified reference material, pharmaceutical secondary standard

象形图

Health hazard
GHS08

警示用语：

Warning

危险声明

H361fd

危险分类

Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number

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Determination of oxytetracycline and its degradation products by high-performance liquid chromatography-tandem mass spectrometry in manure-containing anaerobic test systems
Loke ML, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 783(1), 11-23 (2003)
Simultaneous determination of sulfathiazole and oxytetracycline in honey by derivative spectrophotometry
Salinas F, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 43(3), 244-252 (1991)
Determination of oxytetracycline and doxycycline in pharmaceutical compounds, urine and honey by derivative spectrophotometry
Salinas F, et al.
Analyst, 114(9), 1141-1145 (1989)
C18 columns for the simultaneous determination of oxytetracycline and its related substances by reversed-phase high performance liquid chromatography and UV detection.
Smyrniotakis CG and Archontaki HA
Journal of Pharmaceutical and Biomedical Analysis, 43(2), 506-514 (2007)
Zhenxing Chi et al.
PloS one, 9(7), e102334-e102334 (2014-07-16)
The study investigated the effect of oxytetracycline (OTC) on the anti-oxidative defense system, the structure (hemolysis rate and morphology) and function (ATP enzyme activity) of human red blood cells (hRBCs) to investigate the possible toxic mechanism of OTC to hRBCs.
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