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Merck
CN

1491004

USP

土霉素

United States Pharmacopeia (USP) Reference Standard

别名:

土霉素 二水合物

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About This Item

经验公式(希尔记法):
C22H24N2O9 · 2H2O
CAS号:
分子量:
496.46
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24

等级

pharmaceutical primary standard

API类

oxytetracycline

制造商/商品名称

USP

应用

pharmaceutical (small molecule)

包装形式

neat

SMILES字符串

O.[H][C@@]12[C@@H](O)[C@@]3([H])C(C(=O)c4c(O)cccc4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C

InChI

1S/C22H24N2O9.H2O/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31);1H2/t12-,13-,14+,17+,21-,22+;/m1./s1

InChI key

IBZHEBHGZFICKS-IFLJXUKPSA-N

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Oxytetracycline USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Oxytetracycline Hydrochloride
  • Oxytetracycline Injection
  • Oxytetracycline Tablets
  • Oxytetracycline for Injection
  • Oxytetracycline Hydrochloride Capsules
  • Oxytetracycline Hydrochloride Soluble Powder

生化/生理作用

Antibiotic produced by Streptomyces rimosus.
Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Mode of Resistance: Active efflux, ribosome protection, tetracycline inactivation.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

Sales restrictions may apply.

象形图

Health hazardEnvironment

警示用语:

Warning

危险声明

危险分类

Aquatic Chronic 2 - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Oxytetracycline Hydrochloride
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 3361-3361 (2020)
Oxytetracycline Hydrochloride Soluble Powder
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 3363- 3363 (2013)
Oxytetracycline
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 3359-3359 (2020)
Extralabel use of oxytetracycline.
T Martin-Jimenez et al.
Journal of the American Veterinary Medical Association, 211(1), 42-44 (1997-07-01)
Hrvoje Petković et al.
Microbiology and molecular biology reviews : MMBR, 70(3), 704-728 (2006-09-09)
From a genetic standpoint, Streptomyces rimosus is arguably the best-characterized industrial streptomycete as the producer of oxytetracycline and other tetracycline antibiotics. Although resistance to these antibiotics has reduced their clinical use in recent years, tetracyclines have an increasing role in

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