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Merck
CN

PHR1165

Supelco

萘普生 钠

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:
(S)-6-甲氧基-α-甲基-2-萘乙酸 钠盐
经验公式(希尔记法):
C14H13NaO3
CAS号:
分子量:
252.24
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

Agency

traceable to USP 1457403

API类

naproxen

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES字符串

[Na+].COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O

InChI

1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1

InChI key

CDBRNDSHEYLDJV-FVGYRXGTSA-M

基因信息

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一般描述

Naproxen sodium (NS) is a sodium salt of propionic acid derivative and demonstrates analgesic, anti-pyretic, and anti-inflammatory properties. It exhibits efficiency in being used as an indomethacin in the treatment of acute musculoskeletal disorders. It belongs to the group of nonsteroidal anti-inflammatory drugs (NSAIDS) and acts by inhibiting the activity of both the cyclooxygenase enzymes, COX-1 & COX-2 and further blocking the synthesis of certain prostaglandins. It is administered in the treatment of ankylosing spondylitis, osteoarthritis, rheumatoid disorders, acute gout, mild to moderate pain, tendonitis, bursitis, dysmenorrhea, fever, and migraine headache. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

Naproxen sodium may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and combined dosage forms by chromatographic and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

环加氧酶(前列腺素 H 合成酶 1 和 2)抑制剂。

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Values of analytes vary lot to lot.

附注

To see an example of a Certificate of Analysis for this material enter LRAA7178 in the slot below. This is an example certificate only and may not be the lot that you receive.

相关产品

产品编号
说明
价格

象形图

Health hazardExclamation mark

警示用语:

Danger

危险声明

危险分类

Acute Tox. 4 Oral - Repr. 1A

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


分析证书(COA)

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Simultaneous Estimation of Sumatrirtan succinate and Naproxen Sodium in bulk drug and Pharmaceutical dosage form by RP-HPLC Method
Gondalia R and Dharamsi A
Journal of Drug Delivery and Therapeutics, 3(2), 1-6 (2013)
Simultaneous determination of naproxen sodium and acetaminophen in fixed-dose combinations formulations by first-order derivative spectroscopy: application to dissolution studies
Medina JR, et al.
International Journal of Pharmacy and Pharmaceutical Sciences, 7(3), 183-188 (2015)
Effects of preoperative ibuprofen and naproxen sodium on orthodontic pain
Polat O, et al.
The Angle Orthodontist, 75(5), 791-796 (2005)
Rapid simultaneous determination of sumatriptan succinate and naproxen sodium in combined tablets by validated ultra performance liquid chromatographic method
Reddy YR, et al.
Journal of Analytical and Bioanalytical Techniques , 2(3), 1-6 (2011)
Naproxen sodium, diflunisal, and placebo in the treatment of chronic back pain.
Berry H, et al.
Annals of the Rheumatic Diseases, 41(2), 129-132 (1982)

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