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等级
certified reference material
pharmaceutical secondary standard
质量水平
Agency
traceable to USP 1457403
API类
naproxen
CofA
current certificate can be downloaded
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-30°C
SMILES字符串
[Na+].COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O
InChI
1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1
InChI key
CDBRNDSHEYLDJV-FVGYRXGTSA-M
基因信息
human ... PTGS1(5742) , PTGS2(5743)
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一般描述
Naproxen sodium (NS) is a sodium salt of propionic acid derivative and demonstrates analgesic, anti-pyretic, and anti-inflammatory properties. It exhibits efficiency in being used as an indomethacin in the treatment of acute musculoskeletal disorders. It belongs to the group of nonsteroidal anti-inflammatory drugs (NSAIDS) and acts by inhibiting the activity of both the cyclooxygenase enzymes, COX-1 & COX-2 and further blocking the synthesis of certain prostaglandins. It is administered in the treatment of ankylosing spondylitis, osteoarthritis, rheumatoid disorders, acute gout, mild to moderate pain, tendonitis, bursitis, dysmenorrhea, fever, and migraine headache. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
应用
Naproxen sodium may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and combined dosage forms by chromatographic and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
生化/生理作用
环加氧酶(前列腺素 H 合成酶 1 和 2)抑制剂。
分析说明
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
其他说明
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Values of analytes vary lot to lot.
附注
To see an example of a Certificate of Analysis for this material enter LRAA7178 in the slot below. This is an example certificate only and may not be the lot that you receive.
警示用语:
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Repr. 1A
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Effects of preoperative ibuprofen and naproxen sodium on orthodontic pain
The Angle Orthodontist, 75(5), 791-796 (2005)
Simultaneous determination of naproxen sodium and acetaminophen in fixed-dose combinations formulations by first-order derivative spectroscopy: application to dissolution studies
International Journal of Pharmacy and Pharmaceutical Sciences, 7(3), 183-188 (2015)
Rapid simultaneous determination of sumatriptan succinate and naproxen sodium in combined tablets by validated ultra performance liquid chromatographic method
Journal of Analytical and Bioanalytical Techniques , 2(3), 1-6 (2011)
Validated HPTLC method for simultaneous quantitation of domperidone maleate and naproxen sodium in bulk drug and formulation
Eurasian Journal of Analytical Chemistry, 5(3), 284-292 (2010)
Naproxen sodium, diflunisal, and placebo in the treatment of chronic back pain.
Annals of the Rheumatic Diseases, 41(2), 129-132 (1982)
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