PHR1026
雷尼替丁 盐酸盐
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
N, N Dimethyl-5-[2-(1-methylamine-2-nitrovinyl)-ethylthiomethyl]furfurylamine hydrochloride
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经验公式（希尔记法）:
C13H22N4O3S · HCl
化学文摘社编号:
分子量:
350.86
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
266-333-0
MDL number:
产品名称
雷尼替丁 盐酸盐, Pharmaceutical Secondary Standard; Certified Reference Material
InChI key
GGWBHVILAJZWKJ-CHHCPSLASA-N
InChI
1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9-;
SMILES string
Cl[H].CN\C(NCCSCc1ccc(CN(C)C)o1)=C\[N+]([O-])=O
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. R0150000
traceable to USP 1598405
API family
ranitidine
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
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Biochem/physiol Actions
H2 组胺受体拮抗剂；抗溃疡剂。
H2 histamine receptor antagonist; anti-ulcer agent.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Application
Ranitidine hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using titrimetry and visible spectrophotometry techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
General description
Ranitidine hydrochloride is a H2-receptor antagonist, widely used for the management of hypersecretory conditions and for the treatment of duodenal ulcer.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA5630 in the slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Spectrophotometric determination of ranitidine hydrochloride based on the reaction with p-dimethylaminobenzaldehyde
Narayana B, et al.
Eurasian Journal of Analytical Chemistry, 5(1), 63-72 (2010)
Julien Le Roux et al.
Environmental science & technology, 46(20), 11095-11103 (2012-09-13)
The kinetics of decomposition of the pharmaceutical ranitidine (a major precursor of NDMA) during chloramination was investigated and some decomposition byproducts were identified by using high performance liquid chromatography coupled with mass spectrometry (HPLC-MS). The reaction between monochloramine and ranitidine
Gaia Rocchitta et al.
Analytical chemistry, 84(16), 7072-7079 (2012-07-25)
Ethanol is one of the most widespread psychotropic agents in western society. While its psychoactive effects are mainly associated with GABAergic and glutamatergic systems, the positive reinforcing properties of ethanol are related to activation of mesolimbic dopaminergic pathways resulting in
Shuang Zhang et al.
PloS one, 7(12), e51148-e51148 (2012-12-20)
Stress contributes to a variety of diseases and disorders such as depression and peptic ulcer. The present study aimed to investigate the correlation between stress ulcer and depression in pathogenesis and treatment by using chronic stress depression (CSD), chronic psychological
Peter J Kahrilas et al.
Chest, 143(3), 605-612 (2012-11-03)
Epidemiologic and physiologic studies suggest an association between gastroesophageal reflux disease (GERD) and chronic cough. However, the benefit of antireflux therapy for chronic cough remains unclear, with most relevant trials reporting negative findings. This systematic review aimed to reevaluate the
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