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文件

BP720

维拉帕米 盐酸盐

British Pharmacopoeia (BP) Reference Standard

别名:

（±）-维拉帕米 盐酸盐, 5-[N-（3，4-二甲氧基苯基乙基）甲胺基]-2-（3，4-二甲氧基苯基）-2-异丙基戊腈α； 盐酸盐

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About This Item

线性分子式:
(CH3O)2C6H3CH2CH2N(CH3)(CH2)3C[C6H3(OCH3)2][CH(CH3)2]CN · HCl
CAS号:
152-11-4
分子量:
491.06
Beilstein:
3647093
MDL编号:
MFCD00055208
UNSPSC代码:
41116107
NACRES:
NA.24

等级

pharmaceutical primary standard

API类

verapamil

形式

solid

保质期

limited shelf life, expiry date on the label

制造商/商品名称

BP

mp

142 °C (dec.) (lit.)

应用

pharmaceutical
pharmaceutical small molecule

格式

neat

储存温度

2-8°C

SMILES字符串

Cl.COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC

InChI

1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H

InChI key

DOQPXTMNIUCOSY-UHFFFAOYSA-N

基因信息

human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779)

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相关类别

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Verapamil hydrochloride BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Verapamil Prolonged-release Tablets
  • Verapamil Tablets
  • Verapamil Oral Solution
  • Verapamil Prolonged-release Capsules
  • Verapamil Injection

    • 生化/生理作用

    α1-肾上腺素受体拮抗剂；L型钙通道阻滞剂。阻断平滑肌和心肌中的 L 型 Ca2+ 通道，体外诱导人原发性和转移性结肠癌细胞的凋亡。对 PGP 起作用的抗药性逆转剂，如减少肾小管清除地高辛。增加 Pgp 的基础 ATP 酶活性。Cyp3A4 和 CYP2C6 的底物。

    包装

    Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    其他说明

    Sales restrictions may apply.

    象形图

    Skull and crossbonesEnvironment
    GHS06,GHS09

    警示用语：

    Danger

    危险声明

    H301,H411

    危险分类

    Acute Tox. 3 Oral - Aquatic Chronic 2

    WGK

    WGK 3

    闪点(°F)

    Not applicable

    闪点(°C)

    Not applicable

    Choose from one of the most recent versions:

    分析证书(COA)

    Lot/Batch Number

    Sorry, we don't have COAs for this product available online at this time.

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