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Merck
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48912-U

Sigma-Aldrich

ProClin™ 300

pkg of 50 mL, ProClin™ preservative for use in IVD manufacturing, CMIT/MIT 3 %

别名:

3% 5-氯-2-甲基-4-异噻唑啉-3-酮和2-甲基-4-异噻唑啉-3-酮溶液

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About This Item

UNSPSC代码:
12352201
NACRES:
NA.21

质量水平

300

表单

liquid

保质期

3 yr

包含

Alkyl Carboxylate

组成

CMIT/MIT, 3%

包装

pkg of 50 mL

参数

<45 °C operating temperature

颜色

colorless to light yellow

基质

Modified glycol

工作pH范围

2.5-8.5

pH值（酸碱度）

4.1 (100 g/L)

沸点

189 °C

mp

-40 °C

溶解性

water: soluble

密度

1.03 g/cm3

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相关类别

一般描述

ProClin™ 防腐剂是一种的水溶性杀菌制剂，通常用于延长试剂的保质期。ProClin™ 300 由 3% 的 5-氯-2-甲基-4-异噻唑啉-3-酮(CMIT) 和 2-甲基-4-异噻唑啉-3-酮 (MIT) 组成，溶于含有烷基羧酸盐的无盐专有乙二醇稳定剂中。推荐工作 pH 范围为 2.5 - 8.5。

应用

ProClin™ 300 适用于制备不同的缓冲液，如 ELISA 缓冲液、样品和底物稀释缓冲液，用于单分子阵列（Simoa 分析）和免疫酶分析。此外，ProClin™ 可用于制备储存缓冲液，以储存与冠状病毒核衣壳蛋白偶联的珠子，并用于血清学多重检测。
ProClin™生物杀灭防腐剂能够迅速穿透细胞膜，抑制对细胞呼吸至关重要的特定酶，因此一接触微生物有机体就会立即抑制细胞活性。ProClin™的多个特定毒性位点可以防止微生物产生高水平的耐药性，使ProClin™即使在IVD组份长期存储期间也保持高效。
用于IVD生产。

生化/生理作用

ProClin™ 产品包含例如 CMIT 和 MIT等活性物质，它们可在四个不同的检查点抑制三羧酸循环，分别为丙酮酸脱氢酶、α-酮戊二酸脱氢酶、琥珀酸脱氢酶和NADH脱氢酶。三羧酸循环的抑制可实现对细菌、真菌和酵母的有效广谱杀灭活性。

法律信息

ProClin is a trademark of LANXESS Corp.

免责声明

本品不可用作全球生物杀灭剂法规监管的生物杀灭剂，法规包括但不限于：美国EPA联邦杀虫剂、杀菌剂和灭鼠剂法案，欧盟生物杀灭剂法规，加拿大有害生物管理局，土耳其生物杀灭剂法规，韩国生活化学产品以及生物杀灭剂相关安全管理法（K-BPR）等。

警示用语：

Danger

危险分类

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

储存分类代码

8A - Combustible corrosive hazardous materials

WGK

WGK 3

闪点(°F)

244.4 °F - closed cup

闪点(°C)

118 °C - closed cup

个人防护装备

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCX1276
MKCW5719
MKCW1837
MKCV4372
MKCV6710

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the concentration of active ingredients in ProClin 300?

    ProClin 300 contains a total of 3% active ingredient.

  4. What is the matrix of the ProClin 300?

    ProClin 300 is a viscous solution containing 93-95 % Modified glycol and 2-3 % Alkyl carboxylate.

  5. When would I choose to use ProClin 300?

    ProClin 300 is best used with production runs of standards, controls, and large volume buffers and solutions.  The product is quite viscous and difficult to work with when trying to measure small volumes.

  6. What are the active ingredients in ProClin 300?

    ProClin 300 contains two active ingredients: 5-Chloro-2-methyl-4-isothiazolin-3-one (CMIT, CAS RN 26172-55-4) and 2-Methyl-4-isothiazolin-3-one (MIT, CAS RN 2682-20-4).  

  7. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  8. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  9. What is the density of ProClin 300?

    The density of ProClin 300 is reported as 8.59 pounds per gallon. The specific gravity at 22°C is reported as 1.03 g/mL.

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Annika Nelde et al.
Nature immunology, 22(1), 74-85 (2020-10-02)
T cell immunity is central for the control of viral infections. To characterize T cell immunity, but also for the development of vaccines, identification of exact viral T cell epitopes is fundamental. Here we identify and characterize multiple dominant and
Molecular-biological problems of drug design and mechanism of drug action
GI Khvatova and AV Semeikin
Journal of Pharmacy and Chemistry, 44(12), 651-653 (2011)
SARS-CoV-2 T-cell epitopes define heterologous and COVID-19-induced T-cell recognition
Nelde A, et al.
Research (Washington, D.C.) (2020)
Limor Cohen et al.
Journal of immunological methods, 452, 20-25 (2017-10-19)
Rats are used as animal models for many human diseases. Cytokines can serve as biomarkers indicative of these diseases or disease states. Techniques for measuring cytokine expression levels often do not provide the sensitivity needed to measure these biomarkers in
Single Molecule Arrays for ultra-sensitive detection of rat cytokines in serum
Cohen L, et al.
Journal of Immunological Methods, 452, 20-25 (2018)
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