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Merck
CN
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文件

14606

Sigma-Aldrich

胆固醇

tested according to Ph. Eur.

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别名:
胆固醇素, 3β-羟基-5-胆甾烯, 5-胆甾烯-3β-醇
经验公式（希尔记法）:
C27H46O
CAS号:
57-88-5
分子量:
386.65
Beilstein:
1915888
EC 号:
200-353-2
MDL编号:
MFCD00003646
UNSPSC代码:
41141804
PubChem化学物质编号:
329750548
NACRES:
NA.21

Agency

USP/NF
tested according to Ph. Eur.

质量水平

100

形式

powder

bp

360 °C (lit.)

mp

147-149 °C (lit.)

溶解性

chloroform: soluble 1 gm in 4.5 ml
diethyl ether: soluble 1 gm in 2.8 ml
pyridine: soluble 1 gm in 1.5 ml
H2O: insoluble
acetone: soluble
alcohol: slightly soluble
alcohol: very soluble (Hot)
benzene: soluble
dioxane: soluble
ethyl acetate: soluble
hexane: soluble
oil: soluble
petroleum ether: soluble

密度

1.067 g/mL at 25 °C (lit.)

应用

pharmaceutical (small molecule)

储存温度

2-8°C

SMILES字符串

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

InChI key

HVYWMOMLDIMFJA-DPAQBDIFSA-N

基因信息

human ... POLA1(5422) , TOP2A(7153)
rat ... Ar(24208) , Polb(29240)

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应用

胆固醇用于制备含有卵清蛋白（OVA）的ISCOM，以研究在亲脂性免疫刺激复合物（ISCOM）中掺入蛋白抗原卵清蛋白（OVA）是否诱导非常强的初次免疫应答。它被掺入动物饲料中以研究富含胆固醇饮食的影响。

生化/生理作用

胆固醇是一种占到细胞膜结构成分约20-25％的脂质。它决定了膜的流动性和渗透性，使其可透过水而不是离子和质子。胆固醇还可调节质膜上存在的转运蛋白和信号蛋白的功能。胆固醇合成的主要部位是小肠和肝脏。
所有生物膜的主要成分；总脑脂质中约25%为胆固醇。

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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