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COO原产地证书/COA分析证书

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04599

地高辛

Name: 地高辛
Brand: SIAL

certified reference material, TraceCERT^®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

别名:

异羟基洋地黄毒苷

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About This Item

经验公式（希尔记法）:

C₄₁H₆₄O₁₄

CAS号:

20830-75-5

分子量:

780.94

Beilstein:

77011

EC 号:

244-068-1

MDL编号:

MFCD00003674

UNSPSC代码:

41116107

PubChem化学物质编号:

329747952

NACRES:

NA.24

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等级

certified reference material
TraceCERT^®

质量水平

300

产品线

TraceCERT^®

表单

powder

制造商/商品名称

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

技术

gas chromatography (GC): suitable

应用

food and beverages

包装形式

neat

SMILES字符串

C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@H]2[C@@H](O)C[C@@H](O[C@@H]2C)O[C@H]3[C@@H](O)C[C@@H](O[C@@H]3C)O[C@H]4CC[C@@]5(C)[C@H](CC[C@@H]6[C@@H]5C[C@@H](O)[C@]7(C)[C@H](CC[C@]67O)C8=CC(=O)OC8)C4

InChI

1S/C41H64O14/c1-19-36(47)28(42)15-34(50-19)54-38-21(3)52-35(17-30(38)44)55-37-20(2)51-33(16-29(37)43)53-24-8-10-39(4)23(13-24)6-7-26-27(39)14-31(45)40(5)25(9-11-41(26,40)48)22-12-32(46)49-18-22/h12,19-21,23-31,33-38,42-45,47-48H,6-11,13-18H2,1-5H3/t19-,20-,21-,23-,24+,25-,26-,27+,28+,29+,30+,31-,33+,34+,35+,36-,37-,38-,39+,40+,41+/m1/s1

InChI key

LTMHDMANZUZIPE-PUGKRICDSA-N

基因信息

human ... ATP1A1(476) , ATP1A2(477) , ATP1A3(478) , ATP1A4(480) , ATP1B1(481) , ATP1B2(482) , ATP1B3(483) , FXYD2(486)

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一般描述

This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com

生化/生理作用

一种强心苷，P-糖蛋白 (Pgp) 的底物。

一种强心苷，P-糖蛋白的底物，上调 Pgp 表达和下调 SXR（固醇类异生物受体）。

包装

Bottomless glass bottle. Contents are inside inserted fused cone.

法律信息

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

GHS06,GHS08

警示用语：

Danger

危险声明

H300,H331,H373

预防措施声明

P260 - P264 - P271 - P301 + P310 - P304 + P340 + P311 - P314

危险分类

Acute Tox. 2 Oral - Acute Tox. 3 Inhalation - STOT RE 2

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

法规信息

危险化学品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Lack of evidence of increased mortality among patients with atrial fibrillation taking digoxin: findings from post hoc propensity-matched analysis of the AFFIRM trial.

Mihai Gheorghiade et al.

European heart journal, 34(20), 1489-1497 (2013-04-18)

Digoxin is recommended for long-term rate control in paroxysmal, persistent, and permanent atrial fibrillation (AF). While some analyses suggest an association of digoxin with a higher mortality in AF, the intrinsic nature of this association has not been examined in

Application of permeability-limited physiologically-based pharmacokinetic models: part I-digoxin pharmacokinetics incorporating P-glycoprotein-mediated efflux.

Sibylle Neuhoff et al.

Journal of pharmaceutical sciences, 102(9), 3145-3160 (2013-05-25)

A prerequisite for the prediction of the magnitude of P-glycoprotein (P-gp)-mediated drug-drug interactions between digoxin and P-gp inhibitors (e.g. verapamil and its metabolite norverapamil) or P-gp inducers (e.g. rifampicin) is a predictive pharmacokinetic model for digoxin itself. Thus, relevant in

VEGF secreted by hypoxic Müller cells induces MMP-2 expression and activity in endothelial cells to promote retinal neovascularization in proliferative diabetic retinopathy.

Murilo Rodrigues et al.

Diabetes, 62(11), 3863-3873 (2013-07-26)

In proliferative diabetic retinopathy (PDR), retinal ischemia promotes neovascularization (NV), which can lead to profound vision loss in diabetic patients. Treatment for PDR, panretinal photocoagulation, is inherently destructive and has significant visual consequences. Therapies targeting vascular endothelial growth factor (VEGF)

Urgent management of rapid heart rate in patients with atrial fibrillation/flutter and left ventricular dysfunction: comparison of the ultra-short-acting β1-selective blocker landiolol with digoxin (J-Land Study).

Ryozo Nagai et al.

Circulation journal : official journal of the Japanese Circulation Society, 77(4), 908-916 (2013-03-19)

A rapid heart rate (HR) during atrial fibrillation (AF) and atrial flutter (AFL) in left ventricular (LV) dysfunction often impairs cardiac performance. The J-Land study was conducted to compare the efficacy and safety of landiolol, an ultra-short-acting β-blocker, with those

Functional evidence for physiological mechanisms to circumvent neurotoxicity of cardenolides in an adapted and a non-adapted hawk-moth species.

Georg Petschenka et al.

Proceedings. Biological sciences, 280(1759), 20123089-20123089 (2013-03-22)

Because cardenolides specifically inhibit the Na(+)K(+)-ATPase, insects feeding on cardenolide-containing plants need to circumvent this toxic effect. Some insects such as the monarch butterfly rely on target site insensitivity, yet other cardenolide-adapted lepidopterans such as the oleander hawk-moth, Daphnis nerii

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实验方案

Rapid, Sensitive, and Quantitative LC/MS/MS Determination of Digitoxin and Digoxin in Plasma

Immunoassay-based methods for digitoxin or digoxin exist, but are time consuming, labor intensive, and not selective due to similarities in their chemical structures.

LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18

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地高辛