质量水平
检测方案
≥99.0% (T)
形式
powder
旋光性
[α]20/D +12±1°, c = 2% in 6 M HCl
反应适用性
reaction type: solution phase peptide synthesis
颜色
colorless to white
mp
137-140 °C (lit.)
141-146 °C
应用
peptide synthesis
SMILES字符串
CC(=O)N[C@@H](CC(O)=O)C(O)=O
InChI
1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/t4-/m0/s1
InChI key
OTCCIMWXFLJLIA-BYPYZUCNSA-N
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应用
N-乙酰基-L-天门冬氨酸可用作合成以下物质的反应物:
- 通过选择性还原和酸催化环化反应形成受保护的高丝氨酸γ-内酯。
- 通过环缩合形成外消旋氨基取代琥珀酰亚胺衍生物。
其他说明
综述;大脑中乙酰胆碱合成时的乙酰基供体。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Synthesis and anticonvulsant activity of racemic 2-amino-N-substituted succinimide derivatives
Journal of Pharmaceutical Sciences, 70(2), 192-195 (1981)
Studies on the metabolic pathway of the acetyl group for acetylcholine synthesis.
Biochemical pharmacology, 29(2), 167-174 (1980-02-01)
NeuroImage, 18(4), 847-855 (2003-05-03)
Previous work has suggested that functional reorganization of cortical areas might have a role in limiting the clinical impact of axonal pathology in patients with established multiple sclerosis (MS). Since there is evidence for irreversible tissue damage even in patients
Stroke, 23(11), 1566-1572 (1992-11-01)
The early time course after acute stroke of cerebral N-acetylaspartate, creatine and phosphocreatine, and compounds containing choline was studied in vivo by means of localized water-suppressed proton magnetic resonance spectroscopy. Eight patients with acute stroke were studied serially in the
Neurosurgical focus, 33(6), E4: 1-E4: 7 (2012-12-04)
Despite negative neuroimaging findings using traditional neuroimaging methods such as MRI and CT, sports-related concussions have been shown to cause neurometabolic changes in both the acute and subacute phases of head injury. However, no prospective clinical study has used an
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