物料
flat bottom wells
polycarbonate membrane
polystyrene
质量水平
描述
This 96-well filter plate has a Polycarbonate membrane used for Permeability studies.
无菌性
non-sterile
产品线
MultiScreen®
特点
lid
制造商/商品名称
MultiScreen®
参数
100 μL sample volume (per well)
技术
DNA purification: suitable
activity assay: suitable (with precipitations)
ligand binding assay: suitable
parallel artificial membrane permeation assay (PAMPA): suitable
receptor binding assay: suitable
板尺寸
96 wells
孔最大体积
300 μL
工作体积
125 μL
孔径
0.4 μm pore size
应用
sample preparation
运输
ambient
相关类别
一般描述
MultiScreen Permeability、MultiScreen-IP和MultiScreen Acceptor板支持用于预测被动转运的人工膜策略。
膜具有均匀的孔结构和密度以实现可靠的转运:
- 单个孔最小化候选串扰
- 与自动液体处理系统的兼容性增加了通量
渗透性测定：
- MultiScreen渗透板具有聚碳酸酯膜，可支持用于渗透试验的己烷/十六烷人工层。1
PAMPA测定：
- MultiScreen-IP板具有疏水性PVDF膜，支持PAMPA ASAys的脂质双层。2,3
MultiScreen Acceptor板：
- MultiScreen Acceptor板可以与任一板一起使用，以捕获被动转运的化合物。该板由100% PTFE构成，根据所评估的小分子的电荷，可以改善LC/MS结果。
应用
测定
蛋白质
外形
其他说明
法律信息
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商品
This is a white paper on the Evaluation of the reproducibility of Parallel Artificial Membrane Permeation Assays (PAMPA) using MultiScreen® Filter Plates.
This is a protocol for a Membrane Integrity test for Lipid-PAMPA Artificial Membranes
Combining solubility & PAMPA assays streamlines drug permeability testing.
实验方案
Assays that predict passive absorption of orally administered drugs have become increasingly important in the drug discovery process. As previously described by Faller and Kansy such assays provide rapid, low cost and automation friendly methods to measure a compound’s passive permeability.
相关内容
Successful screening for drug targets and lead discovery requires tested, fit-for-process, high-throughput reagents and supplies. Find tools right for your CRO, pharma or biotech processes for both small molecule and biologics screening, and robust immunogenicity testing for therapeutic safety.
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