产品名称
Multiscreen® 96孔板，疏水性PVDF膜, pore size 0.45 μm, non-sterile
material
flat bottom wells
Durapore PVDF membrane
clear acrylic plate
description
This clear 96 well filter plate has a Hydrophobic PVDF membrane used for PAMPA.
without underdrain
Quality Level
usage
Manual
feature
hydrophobic
lid
packaging
pkg of 10 plates
manufacturer/tradename
MultiScreen®
sterility
non-sterile
technique(s)
cell based assay: suitable
dot blot: suitable
parallel artificial membrane permeation assay (PAMPA): suitable
plate size
96 well
well maximum volume
300 μL
working volume
50-250 μL
matrix
Immobilon®-P
pore size
0.45 μm pore size
binding type
high binding surface
compatibility
manifold only
shipped in
ambient
Application
测定
蛋白质
General description
MultiScreen Permeability、MultiScreen-IP和MultiScreen Acceptor板支持用于预测被动转运的人工膜策略。
膜具有均匀的孔结构和密度以实现可靠的转运:
- 单个孔最小化候选串扰
- 与自动液体处理系统的兼容性增加了通量
渗透性测定：
- MultiScreen渗透板具有聚碳酸酯膜，可支持用于渗透试验的己烷/十六烷人工层。1
PAMPA测定：
- MultiScreen-IP板具有疏水性PVDF膜，支持PAMPA ASAys的脂质双层。2,3
MultiScreen Acceptor板：
- MultiScreen Acceptor板可以与任一板一起使用，以捕获被动转运的化合物。该板由100% PTFE构成，根据所评估的小分子的电荷，可以改善LC/MS结果。
Other Notes
Physical form
Legal Information
商品
Combining solubility & PAMPA assays streamlines drug permeability testing.
This is a white paper on the Evaluation of the reproducibility of Parallel Artificial Membrane Permeation Assays (PAMPA) using MultiScreen® Filter Plates.
This is a protocol for a Membrane Integrity test for Lipid-PAMPA Artificial Membranes
实验方案
Assays that predict passive absorption of orally administered drugs have become increasingly important in the drug discovery process. As previously described by Faller and Kansy such assays provide rapid, low cost and automation friendly methods to measure a compound’s passive permeability.
Guidelines for various bioassays on the MultiScreen system, which makes it possible to carry out an assay from sample incubation to scintillation counting in a 96-well plate.
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