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生物来源
mouse
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
8G11, monoclonal
种属反应性
mouse
技术
flow cytometry: suitable
western blot: suitable
同位素/亚型
IgG2aκ
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... IDO1(3620)
一般描述
Indoleamine 2,3-dioxygenase (IDO) is an enzyme that is responsible for converting tryptophan to kynurenines. IDO is expressed by a wide variety of tissues and can be upregulated by interferon gamma. IDO modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO may be involved in the suppression of the immune response to tumours and blocking the IDO pathway may be a potential target for immunotherapy.
特异性
This antibody does not cross react with Ido2.
免疫原
Recombinant protein corresponding to mouse Ido1.
应用
Anti-Ido1, clone 8G11 Antibody is an antibody against Ido1 for use in Western Blotting, Flow Cytometry.
Western Blotting Analysis: A representative lot detected Ido1 in splenic dendric cells from WT or KO mouse tissue lysate (Oberdan Leo, Universite Libre de Bruxelles).
Flow Cytometry Analysis: A representative lot detected Ido1 in splenic dendric cells from mouse (Oberdan Leo, Universite Libre de Bruxelles).
Flow Cytometry Analysis: A representative lot detected Ido1 in splenic dendric cells from mouse (Oberdan Leo, Universite Libre de Bruxelles).
质量
Evaluated by Western Blotting in Ido1-Flag tag transfected HEK293T cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected Ido1 in 10 µg of Ido1-Flag tag transfected HEK293T cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected Ido1 in 10 µg of Ido1-Flag tag transfected HEK293T cell lysate.
目标描述
~44 kDa observed. Uncharacterized band(s) may appear in some lysates.
外形
Format: Purified
其他说明
Concentration: Please refer to lot specific datasheet.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Marco Gargaro et al.
Immunity, 55(6), 1032-1050 (2022-06-16)
Conventional dendritic cells (cDCs), cDC1 and cDC2, act both to initiate immunity and maintain self-tolerance. The tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) is used by cDCs in maintaining tolerance, but its role in different subsets remains unclear. At homeostasis
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