MABC158
Anti-hyaluronan synthase 1 Antibody, clone 12A2.3
clone 12A2.3, from mouse
别名:
Hyaluronan synthase 1, Hyaluronate synthase 1, Hyaluronic acid synthase 1, HA synthase 1, HuHAS1
产品名称
Anti-hyaluronan synthase 1 Antibody, clone 12A2.3, clone 12A2.3, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
12A2.3, monoclonal
species reactivity
human
technique(s)
immunohistochemistry: suitable
western blot: suitable
isotype
IgMκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HAS1(3036)
Analysis Note
Control
HL-60 cell lysate
HL-60 cell lysate
Evaluated by Western Blotting in HL-60 cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detects hyaluronan synthase 1 in 10 µg of HL-60 cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detects hyaluronan synthase 1 in 10 µg of HL-60 cell lysate.
Application
Anti-hyaluronan synthase 1 Antibody, clone 12A2.3 is a highly specific mouse monoclonal antibody, that targets Hyaluronan synthase 1 & has been tested in western blotting & IHC.
Immunohistochemistry Analysis: A 1:200 dilution from a representative lot detected hyaluronan synthase 1 in human ovarian cancer tissues.
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Apoptosis - Additional
Biochem/physiol Actions
This antibody recognizes the cytoplasmic domain of hyaluronan synthase 1.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Hyaluronan synthase 1 (HAS1) is one of three enzymes, located at the plasma membrane, that synthesizes the glycosaminoglycan hyaluronan or hyaluronic acid (HA). Hyaluronan is involved in cell proliferation, differentiation, angiogenesis, and tumor development, among other cellular processes.
~70 kDa observed
Immunogen
Epitope: Cytoplasmic domain
KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human hyaluronan synthase 1.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Format: Purified
Purified mouse IgMκ supernatant in buffer containing PBS with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
André L Samson et al.
Cell death and differentiation, 28(7), 2126-2144 (2021-02-17)
Necroptosis is a lytic, inflammatory cell death pathway that is dysregulated in many human pathologies. The pathway is executed by a core machinery comprising the RIPK1 and RIPK3 kinases, which assemble into necrosomes in the cytoplasm, and the terminal effector
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