HAS1
hyaluronan synthase 1
别名:
HAS
物种:
Human HAS1 (3036), Mouse Has1 (15116), Rat Has1 (282821), domestic guinea pig Has1 (100712902), naked mole-rat Has1 (101707808), cow HAS1 (282820), dog HAS1 (611700), domestic cat HAS1 (101093224), Zebrafish has1 (403130)
UniProtKB ID:
基因ID:
- Human(3036) Summary: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. [provided by RefSeq, Jul 2008]
- Mouse(15116) hyaluronan synthase1
- Rat(282821) hyaluronan synthase 1
- domestic guinea pig(100712902) hyaluronan synthase 1
- naked mole-rat(101707808) hyaluronan synthase 1
- cow(282820) hyaluronan synthase 1
- dog(611700) hyaluronan synthase 1
- domestic cat(101093224) hyaluronan synthase 1
- Zebrafish(403130) hyaluronan synthase 1
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Antibodies
货号
说明
物种反应性
应用
Anti-HAS1 antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse
应用
immunohistochemistry
western blot
western blot
Anti-hyaluronan synthase 1 Antibody, clone 12A2.3, clone 12A2.3, from mouse,
物种反应性
human
应用
immunohistochemistry
western blot
western blot
Monoclonal Anti-HAS1 antibody produced in mouse, clone 3E10, ascites fluid,
物种反应性
human
应用
ELISA
immunofluorescence
western blot
immunofluorescence
western blot