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Merck
CN

MAB3482

抗囊性纤维化跨膜电导调节剂抗体，克隆MM13-4

clone MM13-4, Chemicon®, from mouse

别名:

CFTR

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
MM13-4, monoclonal
Application:
immunocytochemistry
immunoprecipitation (IP)
western blot
Species reactivity:
human
Citations:
27
Technique(s):
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
Uniprot accession no.:
P13569

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产品名称

抗囊性纤维化跨膜电导调节剂抗体，克隆MM13-4, clone MM13-4, Chemicon®, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

MM13-4, monoclonal

species reactivity

human

should not react with

mouse, shark

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_000492.3

UniProt accession no.

P13569

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... CFTR(1080)

相关类别

Application

使用经验证用于IC、IP & WB的抗囊性纤维化跨膜传导调节蛋白抗体（克隆MM13-4）检测囊性纤维化跨膜传导调节蛋白。
研究子类别
离子通道 & 转运蛋白
研究类别
神经科学
蛋白质印迹：10 μg/mL，可识别CFTR（150-170kDa）和另外两个52kDa和38kDa的蛋白

免疫沉淀

免疫荧光

注意：在石蜡包埋组织上不起作用。

最佳工作稀释度必须由最终用户进行确定。

Biochem/physiol Actions

人囊性纤维化跨膜传导调节蛋白（CFTR）。识别残基24和35之间的N端表位。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

Immunogen

合成肽（RKGYRQRLELSD），对应于人囊性纤维化跨膜传导调节蛋白（CFTR）的残基25-36。

Other Notes

浓度：请参考批次特异性浓缩物的检验报告。

Physical form

形式：纯化
纯化的免疫球蛋白。 液体形式，溶于0.02 M磷酸盐缓冲液、0.25 M NaCl（pH 7.6）和0.1%叠氮化钠中。

Preparation Note

以未稀释等分试样保存于2-8°C下6个月。

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Chunying Li et al.
Methods in molecular biology (Clifton, N.J.), 741, 255-270 (2011-05-20)
Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel localized primarily at the apical surface of epithelial cells lining the airway, gut, exocrine glands, etc., where it is responsible for transepithelial salt and water transport. A growing number of
Ophélia Granio et al.
American journal of respiratory cell and molecular biology, 37(6), 631-639 (2007-07-21)
Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, and the cellular trafficking of the CFTR protein is an essential factor that determines its function in cells. The aim of our study was to
Cysteine string protein interacts with and modulates the maturation of the cystic fibrosis transmembrane conductance regulator.
Zhang, H; Peters, KW; Sun, F; Marino, CR; Lang, J; Burgoyne, RD; Frizzell, RA
The Journal of Biological Chemistry null
Ahmed Lazrak et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(11), 4630-4645 (2013-08-03)
The most common disease-causing mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene is the out-of-frame deletion of 3 nucleotides (CTT). This mutation leads to the loss of phenylalanine-508 (ΔF508) and a silent codon change (SCC) for isoleucine-507 (I507-ATC→ATT).
Shipeng Wei et al.
The Journal of biological chemistry, 289(29), 19942-19957 (2014-05-31)
ATP-binding cassette (ABC) transporters are an ancient family of transmembrane proteins that utilize ATPase activity to move substrates across cell membranes. The ABCC subfamily of the ABC transporters includes active drug exporters (the multidrug resistance proteins (MRPs)) and a unique
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