Anti-Human MT1-MMP catalytic domain Antibody, clone 3G4.2

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP′s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MMP-14 is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. MT1-MMP is capable of mediating pericellular proteolysis of extracellular matrix components and is therefore thought to be an important molecular tool for cellular remodeling of the surrounding matrix. This protein also activates MMP2 protein, and this activity may be involved in tumor invasion.

Clone 3G4.2 recognizes the catalytic domain of MT1-MMP, identifying the active form of the protein. MW is approximately 60 kDa.

Epitope: catalytic domain

Recombinant protein containing the catalytic domain of human MT1-MMP.

Suggested dilutions:
Western blot: 1:1000 - 1:2000

Detect Human MT1-MMP catalytic domain using this Anti-Human MT1-MMP catalytic domain Antibody, clone 3G4.2 validated for use in WB, IC, IH.

Research Category
Cell Structure

Research Sub Category
MMPs & TIMPs

60 kDa

Format: Purified

Protein A purified immunoglobulin liquid in PBS, pH 7.2, containing 0.1% sodium azide.

1 year at 2-8°C from date of shipment

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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