biological source
rabbit
Quality Level
conjugate
peroxidase conjugate
antibody form
F(ab′)2 fragment of affinity isolated antibody
antibody product type
secondary antibodies
clone
polyclonal
species reactivity
mouse
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable, western blot: suitable
shipped in
wet ice
target post-translational modification
unmodified
General description
免疫球蛋白G（IgG） 是在人类血清中发现的最丰富的糖蛋白抗体。它是由B细胞分泌的。IgG结构包含4条多肽链，其中包括两条相同的重（H）链和两条完全相同的λ轻（L）链。这些链通过二硫键相互连接。IgG以IgG1、IgG2、IgG3和IgG4四种亚型存在。
Application
兔抗小鼠IgG抗体，HRP偶联物已用于蛋白质印迹。(1:2000)(1:200000)(1:5000)
Biochem/physiol Actions
免疫球蛋白G（IgG）有助于补体系统的激活。它中和病毒颗粒和毒素。IgG促进抗体依赖性细胞介导的细胞毒性（ADCC）。母体IgG通过胎盘转移到 胎儿 ，这对于保护新生儿免受 传染病的侵害至关重要。检测严重急性呼吸系统综合征冠状病毒（SARS-CoV）2型感染患者的IgG水平可能是评估2019冠状病毒病（COVID-19）严重程度和预后的一种潜在策略。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Elen Rizzi et al.
International journal of cardiology, 165(1), 165-173 (2011-09-16)
Increased oxidative stress upregulates matrix metalloproteinases (MMPs) and transforming grow factor (TGF-β), which are involved in hypertensive cardiac remodeling. We tested the hypothesis that tempol (an antioxidant) could prevent these alterations in two-kidney, one-clip (2K1C) hypertension. Sham-operated or hypertensive rats
S B A Cau et al.
British journal of pharmacology, 164(2), 372-381 (2011-03-26)
Mounting evidence implicates matrix metalloproteinase (MMP) in the vascular dysfunction and remodelling associated with hypertension. We tested the hypothesis that treatment with pyrrolidine dithiocarbamate (PDTC), which interferes with NF-κB-induced MMPs gene transcription, could exert antihypertensive effects, prevent MMP-2 and MMP-9
Neuron-glia communication: metallothionein expression is specifically up-regulated by astrocytes in response to neuronal injury.
Roger S Chung, Paul A Adlard, Justin Dittmann, James C Vickers, Meng Inn Chuah, Adrian K West
Journal of Neurochemistry null
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| AP160P | 04053252506703 |