所有图片(2)
Megakaryocyte-stimulating factor, Superficial zone proteoglycan, articular superficial zone protein, bG174L6.2 (MSF: megakaryocyte stimulating factor ), megakaryocyte stimulating factor, proteoglycan 4, proteoglycan 4, (megakaryocyte stimulating factor,
推荐产品
生物来源
rabbit
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
mouse
种属反应性(根据同源性预测)
human, rat, primate, horse
技术
immunocytochemistry: suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... PRG4(10216)
一般描述
PRG4, Proteoglycan 4, is a human gene and is found in synovial tissue, cartilage, and liver. Small amounts are found in the lung. Isoform 1 is found in the kidney, lung, liver, heart and brain. The other Isoforms, C & D, are widely expressed. PRG4 is a lubricating glycoprotein containing chondroitin sulfate and keratan sulfate glycosaminoglycans. It is responsible for boundary lubrication at the cartilage surface. A disease associated with PRG4 is Jacobs’s syndrome which is an autosomal recessive disorder.
特异性
Cat. # AB2220 recognizes PRG4.
免疫原
Epitope: C-Teminus
KLH-conjugated followed by PRG4 corresponding to the C-terminal region
应用
Anti-PRG4 Antibody is an antibody against PRG4 for use in WB & IC.
Immunocytochemistry:
Confocal IF analysis of N1E-115 using anti-PRG4 (1:500) Rabbit pAB (Red). Actin filaments have been labeled with Alexa Fluor 488 -Phalloidin (Green). Nuclear is stained with DAPI (Blue).
Confocal IF analysis of N1E-115 using anti-PRG4 (1:500) Rabbit pAB (Red). Actin filaments have been labeled with Alexa Fluor 488 -Phalloidin (Green). Nuclear is stained with DAPI (Blue).
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
质量
Western Blotting
目标描述
~37 kDa
外形
Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.
储存及稳定性
Stable for 1 year at 2-8ºC from date of receipt.
分析说明
Control
Mouse Brain lysates
Mouse Brain lysates
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 37(12), 2531-2547 (2022-10-11)
Understanding how obesity-induced metabolic stress contributes to synovial joint tissue damage is difficult because of the complex role of metabolism in joint development, maintenance, and repair. Chondrocyte mitochondrial dysfunction is implicated in osteoarthritis (OA) pathology, which motivated us to study
Biomedical reports, 19(3), 60-60 (2023-08-24)
Suppression of the antitumor cytokine interleukin-24 (IL-24) is critical for the survival of myxoid liposarcoma (MLS) cells. It has been previously demonstrated by the authors that an MLS-specific chimeric oncoprotein, translocated in liposarcoma-CCAAT/enhancer-binding protein homologous protein (TLS-CHOP), supresses IL24 mRNA
Journal of dental research, 94(2), 337-343 (2014-12-17)
Synovial fluid of the joint decreases friction between the cartilage surfaces and reduces cartilage wear during articulation. Characteristic changes of synovial fluid have been shown in patients with osteoarthritis (OA) in the temporomandibular joint (TMJ). OA is generally considered to
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