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Merck
CN

8.17043

SAFC

硫柳汞

EMPROVE® ESSENTIAL, Ph. Eur., BP

制药生产

别名:

Thimerosal

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About This Item

经验公式(希尔记法):
C9H9HgNaO2S
CAS号:
分子量:
404.81
MDL编号:
UNSPSC代码:
12352103
EC索引号:
200-210-4

Agency

BP
Ph. Eur.

质量水平

产品线

EMPROVE® ESSENTIAL

形式

solid

pH值(酸碱度)

6.7 (20 °C, 10 g/L in H2O)

mp

232-233 °C (decomposition)

转变温度

flash point 250 °C

溶解性

1000 g/L

应用

liquid formulation
ophthalmics
pharma/biopharma processes
pharmaceutical
semi-solid formulation

储存温度

15-25°C

InChI

1S/C7H6O2S.C2H5.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H2,2H3;;/q;;2*+1/p-2

InChI key

RTKIYNMVFMVABJ-UHFFFAOYSA-L

一般描述

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

应用

Thimerosal has strong antiseptic and antifungal capabilities and is therefore typically used as preservative in liquid dosage forms of cosmetics and pharmaceutical products.

法律信息

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

As part of the corporation global plan to support the MinamataConvention in eliminating mercury-containing compounds, as of January 2021customers will be required to provide an End-Use Declaration. The sales ofthimerosal will be restricted for approved applications only, such aspreservative in vaccine manufacturing, preservative in eye cosmetics, researchuse within academia (excluding preservation intent) and as reference materialonly. The product is not intended for use as a biocide under global biocideregulations, including but not limited to US EPA′s Federal InsecticideFungicide and Rodenticide Act , European Biocidal Products Regulation, Canada’sPest Management Regulatory Agency, Turkey’s BiocidalProducts Regulation, Korea’s Consumer Chemical Products and BiocideSafety Management Act (K-BPR) and others.

警示用语:

Danger

危险分类

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2 Oral

靶器官

Kidney

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Find key considerations for the selection and use of preservatives in a range of different therapeutic applications including topical, oral, transmucosal, inhalation, and otic, as well as injectables.

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