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质量水平
效能
300-2000 mg/kg LD50, oral (Rat)
mp
70-73 °C
储存温度
2-8°C
SMILES字符串
N21CCOCCOCCN(CCOCCOCC2)CCOCCOCC1
InChI
1S/C18H36N2O6/c1-7-21-13-14-24-10-4-20-5-11-25-17-15-22-8-2-19(1)3-9-23-16-18-26-12-6-20/h1-18H2
InChI key
AUFVJZSDSXXFOI-UHFFFAOYSA-N
应用
- Improved, one-pot synthesis of 6-[(18) F]fluorodopamine and quality control testing for use in patients with neuroblastoma.: This study presents an improved method for synthesizing 6-[(18) F]fluorodopamine using Kryptofix 222. The one-pot synthesis process enhances efficiency and quality control, making it suitable for clinical applications in neuroblastoma patients (Vāvere et al., 2018).
- Efficient radiosynthesis and non-clinical safety tests of the TSPO radioprobe [(18)F]FEDAC: Prerequisites for clinical application.: Kryptofix 222 is utilized in the radiosynthesis of [(18)F]FEDAC, a radioprobe for TSPO imaging. The study highlights the efficiency and safety of the synthesis process, facilitated by Kryptofix 222, and its potential for clinical application (Kawamura et al., 2016).
- Fully automated one-pot radiosynthesis of O-(2-[18F]fluoroethyl)-L-tyrosine on the TracerLab FX(FN) module.: This research demonstrates the automated synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine, employing Kryptofix 222 as a phase transfer catalyst. The automated process significantly improves the synthesis efficiency (Bourdier et al., 2011).
- Electrochemical concentration of no-carrier-added [(18)F]fluoride from [(18)O]water in a disposable microfluidic cell for radiosynthesis of (18)F-labeled radiopharmaceuticals.: Kryptofix 222 plays a crucial role in the electrochemical concentration of [(18)F]fluoride, facilitating the radiosynthesis of various (18)F-labeled radiopharmaceuticals in a microfluidic cell, enhancing the overall efficiency and yield (Saiki et al., 2010).
分析说明
Assay (perchloric acid titration): ≥ 99
Purity (GC): ≥ 99
Identity (IR-spectrum): passes test
Melting point: 69 - 72
Biggest singly impurity (GC): ≤ 0.1 %
Acetone (HS-GC): ≤ 5000 ppm
Acetonitrile (HS-GC): ≤ 410 ppm
Dichloromethane (HS-GC): ≤ 600 ppm
n-Hexane (HS-GC): ≤ 290 ppm
Methanol (HS-GC): ≤ 3000 ppm
petroleum ether (HS-GC): ≤ 290 ppm
Pyridine (HS-GC): ≤ 200 ppm
Sulfated ash: ≤ 0.1 %
Water (according to Karl Fischer): ≤ 0.5
E.coli: passes test
Salmonella species: passes test
Staphylococcus aureus: passes test
Pseudomonas aeruginosa: passes test
Colony count (aerobic bacteria): ≤ 5000 CFU/g
Colony count (Yeasts and moulds): ≤ 500 CFU/g
Endotoxins: ≤ 50 I.U./g
Purity (GC): ≥ 99
Identity (IR-spectrum): passes test
Melting point: 69 - 72
Biggest singly impurity (GC): ≤ 0.1 %
Acetone (HS-GC): ≤ 5000 ppm
Acetonitrile (HS-GC): ≤ 410 ppm
Dichloromethane (HS-GC): ≤ 600 ppm
n-Hexane (HS-GC): ≤ 290 ppm
Methanol (HS-GC): ≤ 3000 ppm
petroleum ether (HS-GC): ≤ 290 ppm
Pyridine (HS-GC): ≤ 200 ppm
Sulfated ash: ≤ 0.1 %
Water (according to Karl Fischer): ≤ 0.5
E.coli: passes test
Salmonella species: passes test
Staphylococcus aureus: passes test
Pseudomonas aeruginosa: passes test
Colony count (aerobic bacteria): ≤ 5000 CFU/g
Colony count (Yeasts and moulds): ≤ 500 CFU/g
Endotoxins: ≤ 50 I.U./g
法律信息
Kryptofix is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
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