Anti-PAI-1 Mouse mAb (MA-33B8)

Purified mouse monoclonal antibody. Recognizes the ~50 kDa PAI-1 protein.

Recognizes the ~50 kDa PAI-1 protein.

This Anti-PAI-1 Mouse mAb (MA-33B8) is validated for use in Immunoblotting, Neutralization Studies for the detection of PAI-1.

Human

human tPA-PAI-1 complex

Immunoblotting (10 µg/ml)

Neutralization Studies (see application references)

Please refer to vial label for lot-specific concentration.

Toxicity: Standard Handling (A)

In 100 mM NaCl, 50 mM sodium phosphate buffer, pH 7.4.

Following initial thaw, aliquot and freeze (-20°C).

Montes, R., et al. 2000. Thromb. Haemost.84, 65.
Verhamme, I., et al. 1999. J. Biol. Chem.274, 17511.
Debrock, S., and Declerck, P.J. 1997. Biochim. Biophys. Acta1337, 257.

Rapidly inactivates PAI-1 (Plasminogen Activator Inhibitor-1) to the latent form. Like the native latent form, PAI-1 inactivated by antibody was protected from cleavage by elastase. Also shown to reduce renal fibrin deposits in a rabbit model of endotoxemia. Variables associated with assay conditions will dictate the proper working dilution.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany