527450
Imidazolo-oxindole PKR inhibitor C16
≥90% (HPLC), solid, PKR inhibitor, Calbiochem®
别名:
PKR 抑制剂
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关于此项目
经验公式（希尔记法）:
C13H8N4OS
化学文摘社编号:
分子量:
268.29
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
PKR 抑制剂, The PKR Inhibitor, also referenced under CAS 608512-97-6, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
SMILES string
[s]1c2c(nc1)ccc3c2\C(=C\c4nc[nH]c4)\C(=O)N3
InChI
1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3-
InChI key
VFBGXTUGODTSPK-BAQGIRSFSA-N
assay
≥90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
orange to orange-brown
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
主要靶标
PKR
PKR
产物不与ATP竞争。
可逆：否
细胞渗透性：否
靶标IC50：210 nM抑制RNA诱导的PKR自磷酸化，100 nM挽救PKR依赖性翻译阻断
Disclaimer
毒性：致癌/致畸（D）
General description
一种咪唑-羟吲哚化合物，作为PKR的一种有效的ATP结合位点定向抑制剂。显示可有效抑制RNA诱导的PKR自磷酸化（IC50 =210 nM）并挽救PKR依赖性翻译阻断（IC50=100 nM）。另提供失活对照。显示可增加持久突触增强的晚期阶段，并增强小鼠的长期记忆。也可以50 mM的DMSO溶液形式（货号527451）提供。
Other Notes
Zhu, P.J., et al. 2011.Cell147, 1384.
Jammi, N.V., et al. 2003.Biochem.Biophys.Res. Commun.308, 50.
Jammi, N.V., et al. 2003.Biochem.Biophys.Res. Commun.308, 50.
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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