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527450

Sigma-Aldrich

Imidazolo-oxindole PKR inhibitor C16

≥90% (HPLC), solid, PKR inhibitor, Calbiochem®

别名:

PKR 抑制剂

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About This Item

经验公式（希尔记法）:
C13H8N4OS
CAS号:
608512-97-6
分子量:
268.29
MDL编号:
MFCD06735404
UNSPSC代码:
12352200
NACRES:
NA.77

产品名称

PKR 抑制剂, The PKR Inhibitor, also referenced under CAS 608512-97-6, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

质量水平

100

方案

≥90% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

orange to orange-brown

溶解性

DMSO: 5 mg/mL

运输

ambient

储存温度

2-8°C

SMILES字符串

[s]1c2c(nc1)ccc3c2\C(=C\c4nc[nH]c4)\C(=O)N3

InChI

1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3-

InChI key

VFBGXTUGODTSPK-BAQGIRSFSA-N

一般描述

一种咪唑-羟吲哚化合物，作为PKR的一种有效的ATP结合位点定向抑制剂。显示可有效抑制RNA诱导的PKR自磷酸化（IC50 =210 nM）并挽救PKR依赖性翻译阻断（IC50=100 nM）。也可以使用非活性对照（目录号 527455。显示可增加持久突触增强的晚期阶段，并增强小鼠的长期记忆。也可以50 mM的DMSO溶液（货号527451）提供。

生化/生理作用

主要靶标
PKR
产物不与ATP竞争。
可逆：否
细胞渗透性：否
靶标IC50：210 nM抑制RNA诱导的PKR自磷酸化，100 nM挽救PKR依赖性翻译阻断

包装

用惰性气体包装

警告

毒性：致癌/致畸（D）

重悬

复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。

其他说明

Zhu, P.J., et al. 2011.Cell147, 1384.
Jammi, N.V., et al. 2003.Biochem.Biophys.Res. Commun.308, 50.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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