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product name
D-myo-Inositol 1,4,5-Trisphosphate, Trisodium Salt, Sodium salt of D-Ins(1,4,5)P₃ that has similar biological properties as the lithium salt.
质量水平
检测方案
≥95% (TLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
颜色
white
溶解性
water: 10 mg/mL
运输
ambient
储存温度
−20°C
InChI
1S/C6H15O15P3.6Na/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12;;;;;;/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18);;;;;;/q;6*+1/p-6/t1-,2+,3+,4-,5-,6-;;;;;;/m1....../s1
InChI key
MLMBGBMAFNSCOW-PPKFVSOLSA-H
相关类别
一般描述
Sodium salt of D-Ins(1,4,5)P3 that has similar biological properties as the lithium salt (Cat. No. 407123).
Sodium salt of D-Ins(1,4,5)P3 that has similar biological properties as the lithium salt (Cat. No. 407123).
生化/生理作用
Cell permeable: no
Primary Target
Mobilization of Ca2+ from intracellular stores.
Mobilization of Ca2+ from intracellular stores.
Product does not compete with ATP.
Reversible: no
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
Ka-Chun Mok et al.
Clinical and translational medicine, 11(11), e578-e578 (2021-11-30)
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are members of the voltage-gated cation channel family known to be expressed in the heart and central nervous system. Ivabradine, a small molecule HCN channel-blocker, is FDA-approved for clinical use as a heart rate-reducing agent.
Jone Paesmans et al.
eLife, 9 (2020-12-23)
Synaptojanin1 (Synj1) is a phosphoinositide phosphatase, important in clathrin uncoating during endocytosis of presynaptic vesicles. It was identified as a potential drug target for Alzheimer's disease, Down syndrome, and TBC1D24-associated epilepsy, while also loss-of-function mutations in Synj1 are associated with
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