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质量水平
检测方案
100.1% dry basis (titration)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
聚集数
2.1
颜色
white to off-white
pKa
3.8
CMC
7.1 mM
溶解性
water: 200 mg/mL
ethanol: soluble
运输
ambient
储存温度
15-25°C
InChI
1S/C26H43NO6.Na/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29;/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33);/q;+1/p-1
InChI key
OABYVIYXWMZFFJ-UHFFFAOYSA-M
一般描述
Formed by the conjugation of cholic acid with glycine. Aggregation number: 2.1.
Glycocholic acid (GCA) is a crystalline secondary bile acid. It is a conjugate of cholic acid and glycine. The microbiota produces GCA in the small intestine by the catalysis of enzymes. Glycocholic Acid, Sodium Salt, an anionic surfactant with a steroidal backbone is soluble in water.Formed by the conjugation of cholic acid with glycine (aggregation number: 2.1; CMC: 7.1 mM; pKa: 3.8).
应用
Glycocholic Acid, Sodium Salt- is suitable for use:
- as a component in the sodium phosphate/NaCl (phosphate buffer saline-PBS) buffer to prepare protein samples
- in the preparation of fluorescently labeled mixed micelles to investigate the uptake by and transport through Caco-2 cells of two mixed micelle formulations of vitamin K
- to prepare mixed micelle solutions to encapsulate a lipid-soluble drug (vitamin K1) to analyze its influence on the quality and stability of the mixed micelle systems
生化/生理作用
Glycocholic acid (GCA) is involved in the emulsification of fats. Glycocholic acid sodium (GAS) salt is one of the important cholic acid salts in the pharmaceutical industry used to prepare mixed micelles (MMs).
警告
Toxicity: Standard Handling (A)
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Tao Wang et al.
Food science & nutrition, 7(11), 3675-3680 (2019-11-26)
Classical mixed micelle systems make excellent parenteral drug carriers for lipophilic or poorly soluble drugs, but many formulations details are not fully understood and need further study. Thus, we constructed mixed micelle systems with lecithin and either glycocholic acid sodium
Feilong Sun et al.
Molecular pharmaceutics, 15(9), 3786-3795 (2018-08-01)
The aim of the study is to investigate the uptake by and transport through Caco-2 cells of two mixed micelle formulations (based on egg phosphatidylcholine and glycocholic acid) of vitamin K, i.e., with and without DSPE-PEG2000. The uptake of vitamin
Cheng Guo et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1072, 315-319 (2017-12-05)
A rapid, accurate and sensitive stable isotope dilution ultra performance liquidchromatography electrospray ionization tandem mass spectrometry (ID-UPLC-ESI-MS/MS) method for the determination of glycocholic acid (GCA) in human serum was developed and validated. Serum samples were spiked with D5-glycocholic acid and
A Braun et al.
Pharmaceutical research, 14(10), 1472-1478 (1997-11-14)
During long-term treatment of various malignant or viral diseases with IFN-alpha up to 20% of patients develop anti-IFN-alpha antibodies for as yet unknown reasons. To address this issue, a mouse model using Balb/C mice was established and the relevance of
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