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Merck
CN

264155

半胱氨酸蛋白酶-3抑制物II

≥90% (TLC), irreversible CPP-32/apopain inhibitor, solid

别名:

半胱氨酸蛋白酶-3抑制物II, Z-D（OMe）E（OMe）VD（OMe）-FMK

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关于此项目

经验公式（希尔记法）:
C30H41FN4O12
化学文摘社编号:
210344-95-9
分子量:
668.66
MDL number:
MFCD23380217
UNSPSC Code:
12352200
NACRES:
NA.77

主要文件

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产品名称

半胱氨酸蛋白酶-3抑制物II, The Caspase-3 Inhibitor II, also referenced under CAS 210344-95-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

SMILES string

FCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)CC(=O)OC)CCC(=O)OC)C(C)C)CC(=O)OC

InChI

1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1

InChI key

GBJVAVGBSGRRKN-JYEBCORGSA-N

assay

≥90% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

white to slightly brown

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

200

相关类别

Biochem/physiol Actions

主要靶标
半胱天冬酶-3，半胱天冬酶-6，半胱天冬酶-7，半胱天冬酶-8，半胱天冬酶-10
产物不与ATP竞争。
可逆：否
细胞可渗透性：是

Disclaimer

毒性：标准处理（A）

General description

CPP-32/Apopain（半胱氨酸蛋白酶的ICE/CED-3家族成员）的有效，细胞可渗透且不可逆的抑制剂。
半胱天冬酶-3以及半胱天冬酶-6、半胱天冬酶-7、半胱天冬酶-8和半胱天冬酶-10的有效，细胞可渗透且不可逆的抑制剂。当与纯化的天然或重组酶一起使用时，需要用酯酶进行预处理。

Other Notes

Thornberry, N.A., and Lazebnik, Y. 1998.Science 281, 1312.
Masuda, Y., et al. 1997.Biochem.Biophys.Res. Commun.234, 641.
Nicholson, D.W.1996.Nature Biotech.14, 297.
Schlegel, J., et al. 1996.J. Biol. Chem. 271, 1841.
Nicholson, D.W., et al. 1995.Nature 376, 37.
Z-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK

Preparation Note

复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Susanna Narkilahti et al.
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