跳转至内容
Merck
CN
所有图片(1)

主要文件

查看所有文档

264155

Sigma-Aldrich

半胱氨酸蛋白酶-3抑制物II

The Caspase-3 Inhibitor II, also referenced under CAS 210344-95-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

别名:

半胱氨酸蛋白酶-3抑制物II, Z-D（OMe）E（OMe）VD（OMe）-FMK

登录查看公司和协议定价
所有图片(1)

About This Item

经验公式（希尔记法）:
C30H41FN4O12
CAS号:
210344-95-9
分子量:
668.66
MDL编号:
MFCD23380217
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

200

方案

≥90% (TLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated

颜色

white to slightly brown

溶解性

DMSO: 5 mg/mL

运输

ambient

储存温度

−20°C

SMILES字符串

FCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)CC(=O)OC)CCC(=O)OC)C(C)C)CC(=O)OC

InChI

1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1

InChI key

GBJVAVGBSGRRKN-JYEBCORGSA-N

一般描述

CPP-32/Apopain（半胱氨酸蛋白酶的ICE/CED-3家族成员）的有效，细胞可渗透且不可逆的抑制剂。
半胱天冬酶-3以及半胱天冬酶-6、半胱天冬酶-7、半胱天冬酶-8和半胱天冬酶-10的有效，细胞可渗透且不可逆的抑制剂。当与纯化的天然或重组酶一起使用时，需要用酯酶进行预处理。

生化/生理作用

主要靶标
半胱天冬酶-3，半胱天冬酶-6，半胱天冬酶-7，半胱天冬酶-8，半胱天冬酶-10
产物不与ATP竞争。
可逆：否
细胞可渗透性：是

警告

毒性：标准处理（A）

序列

Z-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK

重悬

复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。

其他说明

Thornberry, N.A., and Lazebnik, Y. 1998.Science 281, 1312.
Masuda, Y., et al. 1997.Biochem.Biophys.Res. Commun.234, 641.
Nicholson, D.W.1996.Nature Biotech.14, 297.
Schlegel, J., et al. 1996.J. Biol. Chem. 271, 1841.
Nicholson, D.W., et al. 1995.Nature 376, 37.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Susanna Narkilahti et al.
The European journal of neuroscience, 18(6), 1486-1496 (2003-09-27)
It is in dispute whether caspase 3 contributes to status epilepticus (SE)-induced cell loss. We hypothesized that caspase 3-mediated cell death continues beyond the acute phase of SE. We induced SE with either kainic acid or electrical stimulation of the
Jörg Weiske et al.
Methods in molecular biology (Clifton, N.J.), 289, 175-192 (2004-10-27)
In epidermal cells desmosomes represent major sites of basolateral cell-cell contacts that play an important role for epidermal homeostasis. Excess or damaged cells are often removed by apoptosis. To release apoptotic cells from the tissue, intercellular contacts have to be
Nídia De Sousa et al.
Bio-protocol, 8(19), e3039-e3039 (2018-10-05)
Planarians are freshwater flatworms, well known for their ability to regenerate a complete organism from any piece of their body. Furthermore, planarians are constantly growing and degrowing throughout their lives, maintaining a functional and proportioned body. These properties rely on
Tsutomu Tanaka et al.
Autophagy, 18(7), 1629-1647 (2021-11-23)
A253-control: A253 control for LAMP3 stable overexpression; A253- LAMP3: A253 LAPM3 stable overexpression; CASP1: caspase 1; CASP3: caspase 3; CHX: cycloheximide; CTSB: cathepsin B; CTSD: cathepsin D; CQ: chloroquine; DCs: dendritic cells; ER: endoplasmic reticulum; LGALS3: galectin 3; HCV: hepatitis

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门