203820
Guanosine 3′,5′-cyclic Monophosphate, 8-Bromo-, Sodium Salt
Cell-permeable cGMP analog that is more resistant to phosphodiesterases than cGMP.
别名:
Guanosine 3′,5′-cyclic Monophosphate, 8-Bromo-, Sodium Salt, 8-Bromo-cGMP, Br-cGMP, Na
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所有图片(1)
About This Item
经验公式（希尔记法）:
C10H10BrN5O7P · Na
CAS号:
分子量:
446.08
MDL编号:
UNSPSC代码:
41106305
NACRES:
NA.77
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质量水平
方案
≥98% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated
颜色
white
溶解性
water: 200 mg/mL
运输
ambient
储存温度
−20°C
SMILES字符串
[P]1(=O)(O[C@@H]2[C@H](O[C@H]([C@@H]2O)[n]3c4[nH]c(n[c](c4nc3Br)=O)N)CO1)O
InChI
1S/C10H11BrN5O7P/c11-9-13-3-6(14-10(12)15-7(3)18)16(9)8-4(17)5-2(22-8)1-21-24(19,20)23-5/h2,4-5,8,17H,1H2,(H,19,20)(H3,12,14,15,18)/t2-,4-,5-,8-/m1/s1
InChI key
YUFCOOWNNHGGOD-UMMCILCDSA-N
相关类别
一般描述
Cell-permeable cGMP analog that is more resistant to phosphodiesterases than cGMP. Preferentially activates protein kinase G. Inhibits thrombin-stimulated arachidonic acid release in human platelets.
生化/生理作用
Cell permeable: yes
Primary Target
protein kinase G
protein kinase G
Product does not compete with ATP.
Reversible: no
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 week at -20°C.
其他说明
Kwak, B.R., and Jongsma, H.J. 1996. Mol. Cell. Biochem. 157, 93.
Perreault, T., and DeMarte, J. 1993. Am. J. Physiol. 264, H302.
Ruth, P., et al. 1991. Eur. J. Biochem.202, 1339.
Schwarzschild, M.A., and Zigmond, R.E. 1991. J. Neurochem.56, 400.
Perreault, T., and DeMarte, J. 1993. Am. J. Physiol. 264, H302.
Ruth, P., et al. 1991. Eur. J. Biochem.202, 1339.
Schwarzschild, M.A., and Zigmond, R.E. 1991. J. Neurochem.56, 400.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Sinisa Prelic et al.
Frontiers in cellular neuroscience, 17, 1180798-1180798 (2023-06-12)
Olfaction is a crucial sensory modality in insects and is underpinned by odor-sensitive sensory neurons expressing odorant receptors that function in the dendrites as odorant-gated ion channels. Along with expression, trafficking, and receptor complexing, the regulation of odorant receptor function
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