14-404-M
ZAP-70 Protein, active, 20 µg
Active, recombinant, human, full length ZAP-70 containing a C-terminal His6 tag, for use in Kinase Assays.
别名:
70 kDa zeta-chain associated protein, SRK, Syk-related tyrosine kinase
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关于此项目
UNSPSC Code:
12352202
NACRES:
NA.32
eCl@ss:
32160405
Form:
liquid
Biological source:
human
Recombinant:
expressed in Sf21 cells
Mol wt:
Mw 70 kDa
产品名称
ZAP-70 Protein, active, 20 µg, Active, recombinant, human, full length ZAP-70 containing a C-terminal His6 tag, for use in Kinase Assays.
Quality Level
Gene Information
human ... ZAP70(7535)
biological source
human
recombinant
expressed in Sf21 cells
form
liquid
shelf life
6 mo.
mol wt
Mw 70 kDa
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (kinase)
NCBI accession no.
UniProt accession no.
storage temp.
−20°C
Analysis Note
routinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1) substrate peptide
Biochem/physiol Actions
Protein Target: ZAP-70
Target Sub-Family: TK
Zeta-chain-associated protein kinase 70 (ZAP-70) plays a vital role in the development and function of T cells and natural killer cells. It interacts directly with the activated T-cell receptor and regulates downstream signals. In addition, ZAP-70 also mediates B-cell receptor (BCR) signaling. Mutations in ZAP-70 have been associated with severe combined immunodeficiency (SCID), chronic lymphocytic leukemia (CLL) , and the development of autoreactive T cells that attack the joints.
Target Sub-Family: TK
Zeta-chain-associated protein kinase 70 (ZAP-70) plays a vital role in the development and function of T cells and natural killer cells. It interacts directly with the activated T-cell receptor and regulates downstream signals. In addition, ZAP-70 also mediates B-cell receptor (BCR) signaling. Mutations in ZAP-70 have been associated with severe combined immunodeficiency (SCID), chronic lymphocytic leukemia (CLL) , and the development of autoreactive T cells that attack the joints.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Research area: CELL SIGNALING
Product Source: expressed in Sf21 Recombinant, human, full length ZAP-70 containing a C-terminal His6-tag
Zeta-chain-associated protein kinase 70 (ZAP-70) is a cytoplasmic tyrosine kinase that consists of tandem SH2 (tSH2) domains at the beginning, linked with a long linker region, and a tyrosine kinase domain at the C-terminal end.
Product Source: expressed in Sf21 Recombinant, human, full length ZAP-70 containing a C-terminal His6-tag
Zeta-chain-associated protein kinase 70 (ZAP-70) is a cytoplasmic tyrosine kinase that consists of tandem SH2 (tSH2) domains at the beginning, linked with a long linker region, and a tyrosine kinase domain at the C-terminal end.
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Physical form
Ni2+/NTA-agarose
Preparation Note
6 months at -20C
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
10 - Combustible liquids
wgk
WGK 1
ZAP-70: an essential kinase in T-cell signaling
Wang H, et al.
Cold Spring Harbor Perspectives in Biology, 2(5), a002279-a002279 (2010)
The Structural Basis for Activation and Inhibition of ZAP-70 Kinase Domain
Huber RG, et al.
PLoS Computational Biology, 11(10), e1004560-e1004560 (2015)
ZAP-70 in Signaling, Biology, and Disease
Au-Yeung BB, et al.
Annual Review of Immunology, 36, 127-156 (2018)
Experimental Models for Rheumatoid Arthritis
Rikard Holmdahl
Journal of Separation Science, 400-412 (2013)
D H Chu et al.
Immunological reviews, 165, 167-180 (1998-12-16)
The processes of T-cell development and activation employ similar immature and mature receptors as well as similar signal transduction pathways to achieve different outcomes. Many signaling molecules are shared between the receptor signaling pathways, including two families of cytoplasmic protein
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