137672
胆固醇
For Cell Culture, EMPROVE® EXPERT
别名:
3β-羟基-5-胆甾烯, 5-胆甾烯-3β-醇
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关于此项目
经验公式（希尔记法）:
C27H46O
化学文摘社编号:
分子量:
386.65
UNSPSC Code:
12352212
Beilstein/REAXYS Number:
1915888
MDL number:
biological source
synthetic
Quality Level
product line
EMPROVE® EXPERT
bp
360 °C (lit.)
mp
147-149 °C (lit.)
density
1.067 g/mL at 25 °C (lit.)
application(s)
pharma/biopharma processes
pharmaceutical
storage temp.
15-25°C
SMILES string
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
InChI
1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChI key
HVYWMOMLDIMFJA-DPAQBDIFSA-N
General description
SyntheChol® synthetic cholesterol, for Cell Culture Emprove® Expert, is a synthetic cholesterol supplement that has been developed to specifically meet the demands of the life science and biopharmaceutical industries. Due to the synthetic nature of the material, the elimination of animal-derived components reduces the incidence of performance variability in the medium and eliminates safety risks due to adventitious agents associated with these components. With a newly optimized manufacturing process, this product is available in quantities from grams to tons to support your development progress.
Application
This supplement is designed to be added to our chemically defined,animal component-free CHO and insect (Sf-RVN) cell media, as well as HEK-293media for VGT manufacturing. This material has been tested for compatibilitywith CHO and Sf-9 cell lines. Cholesterol provides structure to cellularmembranes, stores energy, and is vital in cell signaling and in regulating cellfunctions.
This product is intended for research or further manufacturing but notfor human or therapeutic use.
This product is intended for research or further manufacturing but notfor human or therapeutic use.
Biochem/physiol Actions
所有生物膜的主要成分；总脑脂质中约25%为胆固醇。
Packaging
137672.0001 /1g /
137672.0010 / 10 g /
137672.0100 / 100 g /
137672.1000 / 1000g /
137672.0010 / 10 g /
137672.0100 / 100 g /
137672.1000 / 1000g /
Legal Information
Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SyntheChol is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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Scott B Widenmaier et al.
Cell, 171(5), 1094-1109 (2017-11-18)
Cholesterol is a critical nutrient requiring tight constraint in the endoplasmic reticulum (ER) due to its uniquely challenging biophysical properties. While the mechanisms by which the ER defends against cholesterol insufficiency are well described, it remains unclear how the ER senses
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 1376720100 | 04065266909876 |
| 1376721000 | 04065266909883 |
| 1376720010 | 04065266881790 |
| 1376720001 | 04065266881974 |