119120
腺苷5′-O-(3-硫代三磷酸)，四锂盐
A relatively stable, slowly hydrolyzable ATP analog that can substitute for ATP in various kinase reactions. Used as a substrate and as an inhibitor of ATP-dependent enzyme systems.
别名:
腺苷5′-O-(3-硫代三磷酸)，四锂盐, ATP-γ-S, 4Li
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About This Item
经验公式（希尔记法）:
C10H12N5O12P3S · 4Li
CAS号:
分子量:
546.98
MDL编号:
UNSPSC代码:
12352208
NACRES:
NA.51
质量水平
检测方案
≥85% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
杂质
<10% ADP
颜色
white
溶解性
water: 10 mg/mL
运输
wet ice
储存温度
−20°C
InChI
1S/C10H16N5O12P3S.4Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31;;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31);;;;/q;4*+1/p-4/t4-,6-,7-,10-;;;;/m1..../s1
InChI key
DWQFDOIBOYDYKH-KWIZKVQNSA-J
一般描述
一种相对稳定、缓慢水解的ATP类似物，可在各种激酶反应中替代ATP。增加Ca2+激活的K+通道的活性。用作ATP依赖性酶系统的底物和抑制剂。
一种相对稳定、缓慢水解的ATP类似物，可在各种激酶反应中替代ATP。增加Ca2+激活的K+通道的活性。用作ATP依赖性酶系统的抑制剂。
应用
- Involvement of purinergic receptors and NOD-like receptor-family protein 3-inflammasome pathway in the adenosine triphosphate-induced cytokine release from macrophages.: This study explores the role of purinergic receptors and the NOD-like receptor-family protein 3 (NLRP3) inflammasome pathway in cytokine release induced by adenosine triphosphate (ATP) in macrophages. The findings suggest potential therapeutic targets for inflammatory diseases (Gicquel et al., 2014).
- Extracellular ATP facilitates flow-induced vasodilatation in rat small mesenteric arteries.: The study demonstrates that extracellular ATP enhances flow-induced vasodilation in small mesenteric arteries in rats, indicating a significant role of ATP in vascular function and potential implications for cardiovascular therapies (Liu et al., 2004).
警告
毒性：标准处理（A）
重悬
在复溶后分装并冻存（-20°C）。储备水溶液在-20°C下可稳定保存3个月。
其他说明
Troadec, J.D., et al. 1999.Pflugers Arch.437, 745.
Chung, S., et al. 1991.Science253, 560.
Litosch, I., and Fain, J.N.1986.Life Sci. 39, 187.
Chrysogelos, S., et al. 1983.J. Biol. Chem.258, 12624.
Chung, S., et al. 1991.Science253, 560.
Litosch, I., and Fain, J.N.1986.Life Sci. 39, 187.
Chrysogelos, S., et al. 1983.J. Biol. Chem.258, 12624.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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