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Merck
CN
所有图片(1)

文件

1.12422

Millipore

N-乙酰基-L-半胱氨酸

for biochemistry

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别名:
N-乙酰基-L-半胱氨酸, 2-乙酰氨基-3-巯基丙酸
经验公式(希尔记法):
C5H9NO3S
CAS号:
分子量:
163.19
MDL编号:
UNSPSC代码:
12352209
EC索引号:
210-498-3
NACRES:
NA.21

蒸汽压

<1 hPa ( 20 °C)

质量水平

形式

solid

效能

5050 mg/kg LD50, oral (Rat)

pH值(酸碱度)

1.5-2.5 (20 °C, 100 g/L in H2O)

mp

110.4 °C

溶解性

179.5 g/L

密度

1.48 g/cm3 at 20 °C

堆积密度

730 kg/m3

储存温度

2-30°C

InChI

1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)

InChI key

PWKSKIMOESPYIA-UHFFFAOYSA-N

应用


  • Development and characterization of a spray-dried inhalable ternary combination for the treatment of Pseudomonas aeruginosa biofilm infection in cystic fibrosis: This study presents a novel N-Acetyl-L-cysteine application in aerosol form designed to treat Pseudomonas aeruginosa biofilm infections in cystic fibrosis patients, highlighting its potential to improve pulmonary function and reduce bacterial colonization (Alhajj et al., 2024).

  • Emetine induces oxidative stress, cell differentiation and NF-κB inhibition, suppressing AML stem/progenitor cells: Research indicates that N-Acetyl-L-cysteine, as part of a combinatory therapy, enhances the oxidative stress response in acute myeloid leukemia, providing a therapeutic strategy for targeting leukemia stem cells (Silva et al., 2024).

  • N-acetylcysteine Treatment in Chronic Obstructive Pulmonary Disease (COPD) and Chronic Bronchitis/Pre-COPD: Distinct Meta-analyses: This meta-analysis reveals N-Acetyl-L-cysteine′s effectiveness in reducing exacerbations and improving antioxidant defense in COPD and chronic bronchitis, suggesting a significant therapeutic benefit in respiratory disease management (Papi et al., 2024).

  • Tannic acid- and N-acetylcysteine-chitosan-modified magnetic nanoparticles reduce hepatic oxidative stress in prediabetic rats: N-Acetyl-L-cysteine, used in modifying magnetic nanoparticles, shows promising results in reducing oxidative stress and liver damage in a prediabetic rat model, underscoring its potential in preventive therapies (Świętek et al., 2024).

  • Phenylarsine oxide induced corneal injury involves oxidative stress mediated unfolded protein response and ferroptotic cell death: Amelioration by NAC: This research outlines N-Acetyl-L-cysteine′s role in mitigating oxidative stress and ferroptosis in corneal cells, providing insights into its protective effects against chemical-induced ocular damage (Kandhari et al., 2023).


分析说明

含量(碘量法): ≥ 99.0%
验证(红外光谱):通过测试
外观:白色至几乎白色,结晶性粉末或无色晶体
溶液外观(1 mol/l,水):透明无色
旋光度 (α 20/D,50  g/l,缓冲液 pH 7.0):+21.0至+27.0
重金属(以铅计): ≤ 0.001 %
NH₄(铵): ≤ 0.01%
L-半胱氨酸(HPLC): ≤ 0.02%
其他茚三酮阳性物质: ≤ 0.1 %

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2

储存分类代码

13 - Non Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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