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线性分子式:
NH2C(CH2OH)3
化学文摘社编号:
分子量:
121.14
EC Index Number:
201-064-4
UNSPSC Code:
12352209
Beilstein/REAXYS Number:
741883
MDL number:
产品名称
高纯度三(羟甲基)胺基甲烷(氨基丁三醇), (Trometamol) high purity, EMPROVE® EXPERT, Ph. Eur., BP, ChP, JPC, USP
SMILES string
NC(CO)(CO)CO
InChI
1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
InChI key
LENZDBCJOHFCAS-UHFFFAOYSA-N
agency
BP
ChP
JPC
Ph. Eur.
USP
vapor pressure
0.0267 hPa ( 20 °C)
description
EMPROVE® EXPERT Ph Eur,BP,JPC,USP,ACS
product line
EMPROVE® EXPERT
form
solid
feature
RNase and DNase free
pH
10.2-10.6 (20 °C, 6 g/L in H2O)
useful pH range
7-9
pKa (25 °C)
8.1
bp
219-220 °C/10 mmHg (lit.)
219-220 °C/13.3 hPa
mp
167-172 °C (lit.)
density
1.35 g/cm3 at 23 °C
application(s)
liquid formulation
pharmaceutical
semi-solid formulation
storage temp.
no temp limit
Quality Level
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Application
Tris(hydroxymethyl)aminomethane (Trometamol) is a commonly used buffer component in biomolecule downstream chromatography steps as well as final liquid formulation.
Due to its low polyoxymethylene limits, Tris(hydroxymethyl)aminomethane (Trometamol) Emprove® Expert is suitable for use at elevated concentrations without risking precipitation. Also, low microbial and endotoxin limits facilitate the use of this product in high-risk applications.
Due to its low polyoxymethylene limits, Tris(hydroxymethyl)aminomethane (Trometamol) Emprove® Expert is suitable for use at elevated concentrations without risking precipitation. Also, low microbial and endotoxin limits facilitate the use of this product in high-risk applications.
General description
Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.
Legal Information
Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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This overview describes the challenges when developing parenteral formulations and strategies to overcome them and reduce the risk of production.
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