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Merck
CN

1.01544

L -精氨酸 单盐酸盐

EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP

别名:

(S)-(+)-2-氨基-5-[(氨基亚甲基)氨基]戊酸 单盐酸盐, (S)-(+)-精氨酸 盐酸盐

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关于此项目

经验公式（希尔记法）:
C6H14N4O2 · HCl
化学文摘社编号:
1119-34-2
分子量:
210.66
EC Index Number:
214-275-1
UNSPSC Code:
12352209
Beilstein/REAXYS Number:
3631658
MDL number:
MFCD00064550

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产品名称

L -精氨酸 单盐酸盐, EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP

SMILES string

Cl[H].N[C@@H](CCCNC(N)=N)C(O)=O

InChI key

KWTQSFXGGICVPE-WCCKRBBISA-N

InChI

1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1

agency

BP
ChP
JP
Ph. Eur.
USP

vapor pressure

<1 Pa ( 20 °C)

product line

EMPROVE® EXPERT

assay

98.5-101.0% dry basis (perchloric acid titration)

form

solid

pH

5.7 (20 °C, 100 g/L in H2O)

mp

>235 °C

solubility

water: 730 g/L at 20 °C

density

1.42 g/cm3 at 20 °C

anion traces

chloride (Cl-): 16.5-17.1%
sulfate (SO42-): ≤200 ppm

cation traces

As: ≤2 ppm
Fe: ≤10 ppm
NH4+: ≤200 ppm
heavy metals (as Pb): ≤10 ppm

application(s)

liquid formulation
parenterals
pharma/biopharma processes
pharmaceutical

storage temp.

2-30°C

Quality Level

500

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相关类别

Biochem/physiol Actions

一氧化氮合成酶的底物，可以转化为瓜氨酸和一氧化氮 (NO)。通过与一氧化氮相关的机理诱导胰岛素释放。

Application

Arginine hydrochloride has several applications in biopharma manufacturing such as an additive for protein refolding, aggregate suppression and buffer for chromatography.
Due to its low microbial and endotoxin limits, L-Arginine monohydrochloride Emprove® Expert is suitable for high-risk applications.

General description

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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