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Merck
CN
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文件

1.01544

SAFC

L -精氨酸 单盐酸盐

EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP

制药生产

别名:

(S)-(+)-2-氨基-5-[(氨基亚甲基)氨基]戊酸 单盐酸盐, (S)-(+)-精氨酸 盐酸盐

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About This Item

经验公式（希尔记法）:
C6H14N4O2 · HCl
CAS号:
1119-34-2
分子量:
210.66
Beilstein:
3631658
MDL编号:
MFCD00064550
UNSPSC代码:
12352209
EC索引号:
214-275-1

Agency

BP
ChP
JP
Ph. Eur.
USP

质量水平

500

蒸汽压

<1 Pa ( 20 °C)

产品线

EMPROVE® EXPERT

检测方案

98.5-101.0% dry basis (perchloric acid titration)

形式

solid

pH值（酸碱度）

5.7 (20 °C, 100 g/L in H2O)

mp

>235 °C

溶解性

water: 730 g/L at 20 °C

密度

1.42 g/cm3 at 20 °C

痕量阴离子

chloride (Cl-): 16.5-17.1%
sulfate (SO42-): ≤200 ppm

痕量阳离子

As: ≤2 ppm
Fe: ≤10 ppm
NH4+: ≤200 ppm
heavy metals (as Pb): ≤10 ppm

应用

liquid formulation
parenterals
pharma/biopharma processes
pharmaceutical

储存温度

2-30°C

SMILES字符串

Cl[H].N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1

InChI key

KWTQSFXGGICVPE-WCCKRBBISA-N

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相关类别

一般描述

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

应用

Arginine hydrochloride has several applications in biopharma manufacturing such as an additive for protein refolding, aggregate suppression and buffer for chromatography.
Due to its low microbial and endotoxin limits, L-Arginine monohydrochloride Emprove® Expert is suitable for high-risk applications.

生化/生理作用

一氧化氮合成酶的底物，可以转化为瓜氨酸和一氧化氮 (NO)。通过与一氧化氮相关的机理诱导胰岛素释放。

法律信息

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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Use of Stabilizers and Surfactants to Prevent Protein Aggregation

This article outlines critical factors in long-term stability of proteins, and how different stabilizers protect again mechanical and thermal stress.

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Formulation

Learn more on mAb subcutaneous or intravenous formulation, and the relevant associated products, including excipients.

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