101500
AEBSF，盐酸盐
AEBSF, CAS 30827-99-7, is a specific irreversible inhibitor of chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. A nontoxic alternative to PMSF and DFP.
别名:
AEBSF，盐酸盐
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关于此项目
经验公式（希尔记法）:
C8H10FNO2S · xHCl
化学文摘社编号:
分子量:
203.23 (free base basis)
UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
产品名称
AEBSF，盐酸盐, AEBSF, CAS 30827-99-7, is a specific irreversible inhibitor of chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. A nontoxic alternative to PMSF and DFP.
SMILES string
F[S](=O)(=O)c1ccc(cc1)CCN.[Cl-].[H+]
InChI
1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
InChI key
WRDABNWSWOHGMS-UHFFFAOYSA-N
assay
>97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated
color
white to off-white
solubility
water: 25 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
主靶
胰凝乳蛋白酶
胰凝乳蛋白酶
产物不与ATP竞争。
Disclaimer
毒性：标准处理（A）
General description
AEBSF，CAS 30827-99-7，是胰凝乳蛋白酶，激肽释放酶，纤溶酶，凝血酶，胰蛋白酶和相关的溶栓酶的特异性不可逆抑制剂。PMSF和DFP的无毒替代品。
丝氨酸蛋白酶的特异性不可逆抑制剂。在活性位点与丝氨酸共价反应。抑制胰凝乳蛋白酶，激肽释放酶，纤溶酶，凝血酶，胰蛋白酶和相关的溶栓酶。PMSF（目录编号52332）的稳定无毒替代品。在大多数应用中，以与PMSF相同的摩尔浓度（0.1-1.0 mM）使用。对蛋白酶K表现出低抑制活性。
Other Notes
Citron, M., et al. 1996.Neuron 17, 171.
Ohkubo, I., et al. 1994.J. Biochem.116, 1182.
Mintz, G.R.1993.BioPharm.6, 34.
Lawson, W.B., et al. 1982.Folia Haematol.109, 52.
Markwardt, F., et al. 1974.Biochem.Pharmacol.23, 2247.
Markwardt, F., et al. 1973.Thromb.Res.2, 343.
Baker, B.R., and Cory, M. 1971.J. Med. Chem.14, 119.
Ohkubo, I., et al. 1994.J. Biochem.116, 1182.
Mintz, G.R.1993.BioPharm.6, 34.
Lawson, W.B., et al. 1982.Folia Haematol.109, 52.
Markwardt, F., et al. 1974.Biochem.Pharmacol.23, 2247.
Markwardt, F., et al. 1973.Thromb.Res.2, 343.
Baker, B.R., and Cory, M. 1971.J. Med. Chem.14, 119.
Packaging
用惰性气体包装
Preparation Note
在复溶后存放于冰箱（4°C）。储备水溶液在4°C下可稳定保存2个月。在碱性pH（8-9）下会发生轻微水解。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1A
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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