101500
AEBSF，盐酸盐
AEBSF, CAS 30827-99-7, is a specific irreversible inhibitor of chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. A nontoxic alternative to PMSF and DFP.
别名:
AEBSF，盐酸盐
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所有图片(1)
About This Item
经验公式（希尔记法）:
C8H10FNO2S · xHCl
CAS号:
分子量:
203.23 (free base basis)
MDL编号:
UNSPSC代码:
12352202
NACRES:
NA.77
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质量水平
方案
>97% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated
颜色
white to off-white
溶解性
water: 25 mg/mL
运输
ambient
储存温度
−20°C
SMILES字符串
F[S](=O)(=O)c1ccc(cc1)CCN.[Cl-].[H+]
1 of 4
此商品 | 33303 | 33300 | 33301 |
|---|---|---|---|
| material white PTFE valve | material white PTFE valve | material white PTFE valve | material white PTFE valve |
| compatibility for use with 20 mm crimp seal | compatibility for use with 20/400 mm thread | compatibility for use with 13/425 mm thread | compatibility for use with 15/425 mm thread |
| packaging pkg of 12 ea | packaging pkg of 12 ea | packaging pkg of 12 ea | packaging pkg of 12 ea |
一般描述
AEBSF，CAS 30827-99-7，是胰凝乳蛋白酶，激肽释放酶，纤溶酶，凝血酶，胰蛋白酶和相关的溶栓酶的特异性不可逆抑制剂。PMSF和DFP的无毒替代品。
丝氨酸蛋白酶的特异性不可逆抑制剂。在活性位点与丝氨酸共价反应。抑制胰凝乳蛋白酶，激肽释放酶，纤溶酶，凝血酶，胰蛋白酶和相关的溶栓酶。PMSF（目录编号52332）和DFP（目录编号30967）的稳定无毒替代品。在大多数应用中，以与PMSF相同的摩尔浓度（0.1-1.0 mM）使用。对蛋白酶K表现出低抑制活性。
生化/生理作用
主靶
胰凝乳蛋白酶
胰凝乳蛋白酶
产物不与ATP竞争。
包装
用惰性气体包装
警告
毒性：标准处理（A）
重悬
在复溶后存放于冰箱（4°C）。储备水溶液在4°C下可稳定保存2个月。在碱性pH（8-9）下会发生轻微水解。
其他说明
Citron, M., et al. 1996.Neuron 17, 171.
Ohkubo, I., et al. 1994.J. Biochem.116, 1182.
Mintz, G.R.1993.BioPharm.6, 34.
Lawson, W.B., et al. 1982.Folia Haematol.109, 52.
Markwardt, F., et al. 1974.Biochem.Pharmacol.23, 2247.
Markwardt, F., et al. 1973.Thromb.Res.2, 343.
Baker, B.R., and Cory, M. 1971.J. Med. Chem.14, 119.
Ohkubo, I., et al. 1994.J. Biochem.116, 1182.
Mintz, G.R.1993.BioPharm.6, 34.
Lawson, W.B., et al. 1982.Folia Haematol.109, 52.
Markwardt, F., et al. 1974.Biochem.Pharmacol.23, 2247.
Markwardt, F., et al. 1973.Thromb.Res.2, 343.
Baker, B.R., and Cory, M. 1971.J. Med. Chem.14, 119.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险声明
危险分类
Eye Dam. 1 - Skin Corr. 1A
储存分类代码
8A - Combustible corrosive hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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