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Merck
CN
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文件

101500

Sigma-Aldrich

AEBSF，盐酸盐

AEBSF, CAS 30827-99-7, is a specific irreversible inhibitor of chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. A nontoxic alternative to PMSF and DFP.

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别名:
AEBSF，盐酸盐
经验公式（希尔记法）:
C8H10FNO2S · xHCl
CAS号:
30827-99-7
分子量:
203.23 (free base basis)
MDL编号:
MFCD00132962
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

100

检测方案

>97% (HPLC)

形式

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated

颜色

white to off-white

溶解性

water: 25 mg/mL

运输

ambient

储存温度

−20°C

InChI

1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H

InChI key

WRDABNWSWOHGMS-UHFFFAOYSA-N

一般描述

AEBSF，CAS 30827-99-7，是胰凝乳蛋白酶，激肽释放酶，纤溶酶，凝血酶，胰蛋白酶和相关的溶栓酶的特异性不可逆抑制剂。PMSF和DFP的无毒替代品。
丝氨酸蛋白酶的特异性不可逆抑制剂。在活性位点与丝氨酸共价反应。抑制胰凝乳蛋白酶，激肽释放酶，纤溶酶，凝血酶，胰蛋白酶和相关的溶栓酶。PMSF（目录编号52332）和DFP（目录编号30967）的稳定无毒替代品。在大多数应用中，以与PMSF相同的摩尔浓度（0.1-1.0 mM）使用。对蛋白酶K表现出低抑制活性。
丝氨酸蛋白酶的特异性不可逆抑制剂。抑制胰凝乳蛋白酶，激肽释放酶，纤溶酶，凝血酶，胰蛋白酶和相关的溶栓酶。PMSF（目录编号52332）和DFP（目录编号30967）的稳定无毒替代品。一种β-分泌酶抑制剂，在毫摩尔浓度下抑制β-淀粉样肽（Aβ）的产生，并增强几种细胞系中淀粉样前体蛋白（sAPPUα）的分泌。在大多数应用中，以与PMSF相同的摩尔浓度（0.1-1.0 mM）使用。也可以50 mM的H2O溶液（目录编号508436）提供。

生化/生理作用

主靶
胰凝乳蛋白酶
产物不与ATP竞争。

包装

用惰性气体包装

警告

毒性：标准处理（A）

重悬

在复溶后存放于冰箱（4°C）。储备水溶液在4°C下可稳定保存2个月。在碱性pH（8-9）下会发生轻微水解。

其他说明

Citron, M., et al. 1996.Neuron 17, 171.
Ohkubo, I., et al. 1994.J. Biochem.116, 1182.
Mintz, G.R.1993.BioPharm.6, 34.
Lawson, W.B., et al. 1982.Folia Haematol.109, 52.
Markwardt, F., et al. 1974.Biochem.Pharmacol.23, 2247.
Markwardt, F., et al. 1973.Thromb.Res.2, 343.
Baker, B.R., and Cory, M. 1971.J. Med. Chem.14, 119.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

Corrosion
GHS05

警示用语：

Danger

危险声明

H314

危险分类

Eye Dam. 1 - Skin Corr. 1A

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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