05-840
抗IDO（吲哚胺 2,3-双加氧酶）抗体，克隆10.1
clone 10.1, Upstate®, from mouse
别名:
Indoleamine 2,3-dioxygenase, Indoleamine-pyrrole 2,3-dioxygenase, indole 2,3-dioxygenase, indoleamine-pyrrole 2,3 dioxygenase, IDO1
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
10.1, monoclonal
Species reactivity:
human, mouse
Application:
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Technique(s):
immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
Citations:
26
Uniprot accession no.:
产品名称
抗IDO（吲哚胺 2,3-双加氧酶）抗体，克隆10.1, clone 10.1, Upstate®, from mouse
biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
10.1, monoclonal
species reactivity
human, mouse
manufacturer/tradename
Upstate®
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
Quality Level
Gene Information
human ... IDO1(3620)
mouse ... Ido1(15930)
Analysis Note
对照
人IFN-γ刺激HeLa细胞裂解物，IFNγ刺激人外周血淋巴细胞。
人IFN-γ刺激HeLa细胞裂解物，IFNγ刺激人外周血淋巴细胞。
已通过蛋白质印迹对未经处理和经IFNγ处理（24 hrs）的Hela裂解液进行了常规评估。
蛋白质印迹分析：
该批次的1:500稀释液在10 ug未处理和IFNγ处理的Hela裂解液中检测到IDO。
蛋白质印迹分析：
该批次的1:500稀释液在10 ug未处理和IFNγ处理的Hela裂解液中检测到IDO。
Application
免疫细胞化学：先前批次已被独立实验室用于表达载体转染的Phoenix细胞中。
免疫组化：该抗体的先前批次用于检测人视网膜、原发性眼肿瘤和转移性肝肿瘤组织切片中的IDO（Chen, P.W., et al. Experimental Eye Research 85(2007) 617-625）。
免疫组化：该抗体的先前批次用于检测人视网膜、原发性眼肿瘤和转移性肝肿瘤组织切片中的IDO（Chen, P.W., et al. Experimental Eye Research 85(2007) 617-625）。
抗IDO（吲哚胺2，3-双加氧酶）抗体，克隆10.1是用于IC & WB的抗IDO（吲哚胺2）的抗体。
Biochem/physiol Actions
识别IDO（吲哚胺 2,3-双加氧酶），Mr 42 kDa。
General description
吲哚胺2，3-双加氧酶（IDO）是一种负责将色氨酸转化为犬尿氨酸的酶。IDO在多种组织中表达，并且IDO可以被干扰素γ上调。IDO调节氨基酸色氨酸的水平，这对细胞生长至关重要，但也参与抑制免疫反应。IDO可能参与抑制对肿瘤的免疫反应，阻断IDO途径可能是免疫治疗的潜在靶标。
42 kDa
Immunogen
GST融合蛋白，对应人吲哚胺 2,3-双加氧酶（IDO）的78-184位残基。克隆10.1。
Other Notes
替代：04-1056
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
形式：纯化
纯化的小鼠单克隆IgG，溶于含有70%储存缓冲液（0.1 M Tris-甘氨酸（pH 7.4）、0.15 M NaCl、0.05％叠氮化钠）和30％甘油的缓冲液中。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
David H Munn et al.
Science (New York, N.Y.), 297(5588), 1867-1870 (2002-09-14)
Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers
Sewha Kim et al.
Journal of Cancer, 8(1), 124-130 (2017-01-27)
Indoleamine 2,3-dioxygenase 1 (IDO1) is an immunosuppressive enzyme involved in tumor immune escape. Blockade of the IDO1 pathway is an emerging modality of cancer immunotherapy. Triple-negative breast cancer (TNBC) lacks established therapeutic targets and may be a good candidate for
M W Taylor et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 5(11), 2516-2522 (1991-08-01)
Interferons have been shown to be potential anti-cancer agents and to inhibit tumor cell growth in culture. The in vivo mechanism of the anti-proliferative effect may be direct or indirect through the immune system; however, in vitro a primary mechanism
Annabel Meireson et al.
Frontiers in immunology, 12, 736498-736498 (2021-09-25)
Immune escape is an early phenomenon in cancer development/progression. Indoleamine 2,3-dioxygenase 1 (IDO1) is a normal endogenous mechanism of acquired peripheral immune tolerance and may therefore be tumor-promoting. This study investigated the clinical relevance of IDO1 expression by immune cells
Ying Lu et al.
Blood, 119(4), 1075-1085 (2011-12-02)
Allogeneic hematopoietic stem cell transplantation (HSCT) can eradicate chemorefractory leukemia through the graft-versus-leukemia (GVL) activity of donor T cells. However, the clinical success of allo-HSCT is limited by the graft-versus-host disease (GVHD) activity of donor T cells. We have reported
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