04-953
抗磷酸化-Smad2（Ser465/467）抗体，克隆A5S，兔单克隆
culture supernatant, clone A5S, Upstate®
别名:
Anti-Anti-CHTD8, Anti-Anti-JV18, Anti-Anti-JV18-1, Anti-Anti-LDS6, Anti-Anti-MADH2, Anti-Anti-MADR2, Anti-Anti-hMAD-2, Anti-Anti-hSMAD2
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选择尺寸
关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
A5S, monoclonal
Species reactivity:
human, zebrafish, mouse, canine
Application:
western blot
Technique(s):
western blot: suitable
Citations:
30
Uniprot accession no.:
产品名称
抗磷酸化-Smad2（Ser465/467）抗体，克隆A5S，兔单克隆, culture supernatant, clone A5S, Upstate®
biological source
rabbit
antibody form
culture supernatant
antibody product type
primary antibodies
clone
A5S, monoclonal
species reactivity
human, zebrafish, mouse, canine
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
phosphorylation (pSer465/pSer467)
Quality Level
Gene Information
human ... SMAD2(4087)
Analysis Note
对照
HL60细胞裂解液，经TGFa处理的HepG2细胞或经TGF处理的HepG2细胞β
HL60细胞裂解液，经TGFa处理的HepG2细胞或经TGF处理的HepG2细胞β
已通过免疫印迹分析进行常规评估。
Application
使用抗磷酸化Smad2（Ser465/467）抗体，克隆A5S（兔单克隆抗体）检测磷酸化Smad2（Ser465/467），该抗体已证明可在WB中发挥作用。
Biochem/physiol Actions
根据序列同源性预测与非洲爪蟾发生交叉反应。
识别磷酸化Smad2。与Smad3没有交叉反应。
General description
55-60 kDa
SMAD2或MAD-mothers against decapentaplegic-homolog是一种多肽，顾名思义，是果蝇基因：“Mothers against decepentaplegic”的同系物它属于SMAD蛋白家族，该家族又属于TGFb调节子超家族。像其他许多TGFb家族成员一样，SMAD2液参与细胞信号转导的调节。SMAD2可调节激活素和TGFb′s的信号。它可与SMAD锚相互作用激活受体（SARA）。配体的结合会引起SMAD2蛋白的磷酸化，从而与SARA的解离并与SMAD4缔合。随后，它被转移至细胞核，与其他蛋白质形成复合物并充当转录因子。SMAD2是受受体调节的SMAD（R-SMAD），并由骨形态发生蛋白1型受体激酶激活。
Immunogen
对应于人Smad2 Ser465/467位点周围氨基酸[pS]M[pS]的KLH偶联合成肽
Other Notes
替代：05-953
浓度：请参考批次特异性浓缩物的分析证书。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 2
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Journal of Veterinary Internal Medicine null
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Cancer letters, 360(2), 134-140 (2015-02-11)
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