推荐产品
生物来源
rabbit
质量水平
抗体形式
culture supernatant
抗体产品类型
primary antibodies
克隆
A5S, monoclonal
种属反应性
human, zebrafish, mouse, canine
制造商/商品名称
Upstate®
技术
western blot: suitable
同位素/亚型
IgG
NCBI登记号
UniProt登记号
运输
dry ice
靶向翻译后修饰
phosphorylation (pSer465/pSer467)
基因信息
human ... SMAD2(4087)
一般描述
SMAD2或MAD-mothers against decapentaplegic-homolog是一种多肽，顾名思义，是果蝇基因：“Mothers against decepentaplegic”的同系物它属于SMAD蛋白家族，该家族又属于TGFb调节子超家族。像其他许多TGFb家族成员一样，SMAD2液参与细胞信号转导的调节。SMAD2可调节激活素和TGFb′s的信号。它可与SMAD锚相互作用激活受体（SARA）。配体的结合会引起SMAD2蛋白的磷酸化，从而与SARA的解离并与SMAD4缔合。随后，它被转移至细胞核，与其他蛋白质形成复合物并充当转录因子。SMAD2是受受体调节的SMAD（R-SMAD），并由骨形态发生蛋白1型受体激酶激活。
特异性
根据序列同源性预测与非洲爪蟾发生交叉反应。
识别磷酸化Smad2。与Smad3没有交叉反应。
免疫原
对应于人Smad2 Ser465/467位点周围氨基酸[pS]M[pS]的KLH偶联合成肽
应用
使用抗磷酸化Smad2（Ser465/467）抗体，克隆A5S（兔单克隆抗体）检测磷酸化Smad2（Ser465/467），该抗体已证明可在WB中发挥作用。
质量
已通过免疫印迹分析进行常规评估。
目标描述
55-60 kDa
联系
替代：05-953
分析说明
对照
HL60细胞裂解液，经TGFa处理的HepG2细胞或经TGF处理的HepG2细胞β
HL60细胞裂解液，经TGFa处理的HepG2细胞或经TGF处理的HepG2细胞β
其他说明
浓度：请参考批次特异性浓缩物的分析证书。
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
未找到合适的产品？
试试我们的产品选型工具.
储存分类代码
10 - Combustible liquids
WGK
WGK 2
Bedrich L Eckhardt et al.
PloS one, 13(5), e0195932-e0195932 (2018-05-17)
Inflammatory breast cancer (IBC) is a rare and aggressive presentation of invasive breast cancer with a 62% to 68% 5-year survival rate. It is the most lethal form of breast cancer, and early recognition and treatment is important for patient
Shunsuke Sawada et al.
Molecular medicine reports, 13(3), 2023-2031 (2016-01-20)
Cytokines and their intercellular signals regulate the multipotency of mesenchymal stem cells (MSCs). The present study established the MSC lines SG‑2, ‑3, and ‑5 from the bone marrow of green fluorescent protein (GFP)‑transgenic mice. These cell lines clearly expressed mouse
R F Portela et al.
Journal of veterinary internal medicine, 28(3), 894-904 (2014-04-02)
Transforming growth factor beta 1 (TGFβ1) is a pleiotropic cytokine that contributes to reparative skeletal remodeling by inducing osteoblast proliferation, migration, and angiogenesis. Organic bone matrix is the largest bodily reservoir for latent TGFβ1, and active osteoblasts express cognate receptors
Amrita Chatterjee et al.
Cancer letters, 360(2), 134-140 (2015-02-11)
The mammalian target of rapamycin complex 1 (mTORC1) is a critical regulator of G1 cell cycle progression. Two key substrates of mTORC1 are ribosomal subunit S6 kinase (S6K) and eukaryotic initiation factor 4E (eIF4E) binding protein-1 (4E-BP1). We reported previously
Josephina A N Meester et al.
Genetics in medicine : official journal of the American College of Medical Genetics, 19(4), 386-395 (2016-09-16)
Thoracic aortic aneurysm and dissection (TAAD) is typically inherited in an autosomal dominant manner, but rare X-linked families have been described. So far, the only known X-linked gene is FLNA, which is associated with the periventricular nodular heterotopia type of
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门