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安全信息

K-002

Supelco

盐酸氯胺酮标准液 盐酸盐 溶液

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

经验公式（希尔记法）:
C13H17Cl2NO
CAS号:
1867-66-9
分子量:
274.19
EC 号:
200-659-6
UNSPSC代码:
41116107
NACRES:
NA.24

等级

certified reference material

质量水平

300

表单

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

drug control

psicótropo (Spain)

浓度

1.0 mg/mL in methanol (as free base)

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

forensics and toxicology

包装形式

single component solution

储存温度

−20°C

SMILES字符串

[Cl-].Clc1c(cccc1)C2(CCCCC2=O)NC.[H+]

InChI

1S/C13H16ClNO.ClH/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14;/h2-3,6-7,15H,4-5,8-9H2,1H3;1H

InChI key

VCMGMSHEPQENPE-UHFFFAOYSA-N

基因信息

human ... GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRIN3A(116443) , GRIN3B(116444)

一般描述

此认证溶液标准品可作为校准物或对照品中的起始材料，通过LC/MS或GC/MS，用于从法医分析和临床毒理学到尿液药物测试方面的各种应用中。

氯胺酮是一种苯环利定类型的麻醉药物，可阻断神经元上的 N-甲基-d-天冬氨酸（NMDA）受体。由于欣快和致幻作用，它也是一种滥用药物。这种药物由于其强力的致幻和解离特性，也在俱乐部、狂欢派对或聚会上被滥用，并且被一些医生开列为抑郁症的非处方疗法。

应用

该认证标准溶液（CRM）还可作如下用途：
  • 开发手性液相色谱-串联质谱（LC-MS/MS）方法以定量小鼠血浆、脑和脑脊液中的氯胺酮和去甲氯胺酮对映体
  • 通过近红外光谱（NIR）法对检获毒品样品中的氯胺酮、甲基苯丙胺、海洛因和可卡因进行多残留无损分析
  • 使用分散液液微萃取（DLLME）和气相色谱-质谱法（GC-MS）检测和评价人尿样品中的氯胺酮、游离甲基苯丙胺、哌替啶和曲马多
  • 使用金属-有机框架/石墨烯纳米复合材料（MOFs@G）修饰的丝网印刷电极（SPE），在表面分子印迹膜 UV 聚合后通过电化学方法测定人尿样品中的氯胺酮
  • 通过 LC-MS/MS 对人尿样品进行四步液-液萃取，同时分析氯胺酮、GHB、诺氯胺酮、苯巴比妥、硫喷妥、唑吡坦、佐匹克隆和苯妥英

特点和优势

  • 完全符合 ISO/IEC 17025 和 ISO 17034 认证
  • 附综合分析证书（CoA），包括稳定性、均匀性、浓度准确性、不确定性和可追溯性数据
  • 通过实时稳定性研究严格测试，以确保准确性和保质期
  • 使用合格的精密天平进行重量准备，以确保最小不确定性
  • 氩气环境下火焰密封，装入安瓿以便长期保存
  • 提供方便的 DEA 豁免格式，以提高实验室效率

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

靶器官

Eyes

储存分类代码

3 - Flammable liquids

WGK

WGK 2

闪点(°F)

49.5 °F - closed cup

闪点(°C)

9.7 °C - closed cup

法规信息

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历史批次信息供参考:

分析证书(COA)

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Ketamine-medetomidine regimen for chemical immobilisation of free-ranging chimpanzees (Pan troglodytes schweinfurthii) in Uganda.
D Hyeroba et al.
The Veterinary record, 172(18), 475-475 (2013-04-02)
Kaixin Fu et al.
Biosensors & bioelectronics, 143, 111636-111636 (2019-09-03)
Ketamine is one of the most widely abused drugs in the world and poses a serious threat to human health and social stability; therefore, the ability to accurately monitor the substance in real-time is necessary. However, several problems still exists
Peter Sos et al.
Neuro endocrinology letters, 34(4), 287-293 (2013-06-28)
Ketamine and other NMDA (N-methyl-D-aspartate) antagonists produce fast-acting antidepressant-like effects, although the underlying mechanism is unclear. Furthermore, high affinity NMDA antagonists such as ketamine are associated with psychotomimetic effects. To date the link between the antidepressant and psychotomimetic effects of
Ege T Kavalali et al.
The American journal of psychiatry, 169(11), 1150-1156 (2013-03-28)
Recent clinical studies have demonstrated that a single subpsychotomimetic dose of ketamine, an ionotropic glutamatergic N-methyl-D-aspartate (NMDA) receptor antagonist, produces a rapid antidepressant response in patients with major depressive disorder, with effects lasting up to 2 weeks. Despite enthusiasm about
Waikwong Tang et al.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 33(2), 164-169 (2013-06-26)
To explore the distribution of TCM patterns in ketamine users and the inter-rater reliability of TCM diagnosis among TCM practitioners. Eighty-four subjects recruited from substance abuse clinics and non-governmental counseling services catering for ketamine abusers were examined by one or
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