推荐产品
等级
certified reference material
质量水平
表单
liquid
特点
SNAP-N-SPIKE®, SNAP-N-SHOOT®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
1.0 mg/mL in methanol
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
clinical testing
包装形式
single component solution
储存温度
−20°C
SMILES字符串
CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24
InChI
1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
InChI key
QZUDBNBUXVUHMW-UHFFFAOYSA-N
基因信息
human ... DRD2(1813) , HTR2A(3356)
一般描述
经认证的Snap-N-Spike®溶液，用于通过LC/MS或GC/MS进行的临床毒理学，法医分析或尿液药物测试应用。氯氮平在美国以Clozaril®和FazaClo®出售，是一种非典型的抗精神病药物，用于精神分裂症的治疗。
应用
- 对氯氮平无反应患者的增强策略：一项贝叶斯网络-元分析评估了对于氯氮平只有部分反应或者没有反应的精神分裂症患者的药效增强策略，该分析提供了有关有效二次治疗方案的见解（Mishra et al., 2024）。
- 抗精神病药物预先治疗和氯氮平代谢：研究重点介绍了在氯氮平治疗以前抗精神病药物快速代谢的影响，该治疗影响了血清水平，说明在治疗难治型精神分裂症的过程中需要调整用药剂量策略（Lenk HÇ et al., 2024）。
- 氯氮平副作用的遗传影响：研究确定了ERBB4和TACR1基因中与氯氮平治疗患者口干症相关的的多态性，指出了针对副作用的个性化管理策略（Puolakka等人，2024）。
- 抗精神病药物的治疗机制：该分析重点关注的是对于抗精神病药物（包括氯氮平）治疗机制的理解，考察了细胞靶点和分子靶点及其对精神疾病治疗效果优化的影响（Direktor et al., 2024）。
- 氯氮平与精神分裂症代谢综合征：该研究评估了以氯氮平治疗并且具有代谢综合征的精神分裂症患者中细胞因子水平、精神病理学和认知功能之间的关联，为整体疗法提供了关键数据（Dong et al., 2024）。
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Clozaril is a registered trademark of Sandoz, Inc.
FazaClo is a registered trademark of Jazz Pharmaceuticals International III Limited
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes,Central nervous system
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
49.5 °F - closed cup
闪点(°C)
9.7 °C - closed cup
法规信息
危险化学品
Chun-Hsin Chen et al.
The Journal of clinical psychiatry, 74(5), e424-e430 (2013-06-14)
Many studies have shown that metformin can decrease body weight and improve metabolic abnormalities in patients with schizophrenia. Whether or not the beneficial effects can be sustained after discontinuation of metformin needs to be evaluated. We conducted a 24-week randomized
Galvin Vredenburg et al.
Toxicology letters, 222(3), 247-256 (2013-08-07)
Clozapine, an often-prescribed antipsychotic drug, is implicated in severe adverse drug reactions (ADRs). Formation of reactive intermediates by cytochrome P450s (CYPs) has been proposed as a possible explanation for these ADRs. Moreover, a protective role for human glutathione S-transferases (hGSTs)
Shalini Jain et al.
The Journal of clinical investigation, 123(4), 1750-1762 (2013-03-13)
Type 2 diabetes (T2D) has emerged as a major threat to human health in most parts of the world. Therapeutic strategies aimed at improving pancreatic β cell function are predicted to prove beneficial for the treatment of T2D. In the
Chao-Cheng Lin et al.
Journal of clinical psychopharmacology, 33(2), 211-214 (2013-02-21)
Clozapine is the most effective antipsychotic for patients with treatment-refractory schizophrenia, but many adverse effects are noted. Clinicians usually hesitate to switch from clozapine to other antipsychotics because of the risk of a re-emergence or worsening of the psychosis, although
Bianca A Silva et al.
Nature neuroscience, 16(12), 1731-1733 (2013-11-12)
The neural circuits mediating fear to naturalistic threats are poorly understood. We found that functionally independent populations of neurons in the ventromedial hypothalamus (VMH), a region that has been implicated in feeding, sex and aggression, are essential for predator and
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