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D-048

N-去甲基氯氮平标准液 CRM 溶液

Name: N-去甲基氯氮平标准液 CRM 溶液
Brand: CERILLIAN

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

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关于此项目

经验公式（希尔记法）:

C₁₇H₁₇ClN₄

化学文摘社编号:

6104-71-8

分子量:

312.80

UNSPSC Code:

41116107

MDL number:

MFCD00210189

NACRES:

NA.24

EC Number:

200-659-6

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属性

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike^®/Snap-N-Shoot^®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant^®

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

shipped in

wet ice

storage temp.

−20°C

SMILES string

Clc1ccc2Nc3ccccc3C(=Nc2c1)N4CCNCC4

InChI

1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19-20H,7-10H2

InChI key

JNNOSTQEZICQQP-UHFFFAOYSA-N

说明

General description

N-去甲基氯氮平是氯氮平的活性代谢物，而后者是治疗精神分裂症的非典型抗精神病药物。氯氮平在美国以Clozaril和FrazaClo^®商品名出售。此款Snap-N-Spike^®溶液经过认证，适用于尿液药物检测、临床毒理学、法医分析以及LC-MS/MS或GC/MS法临床监测。

Other Notes

2024年CiteAb奖，授予在帕金森研究方面取得成功的供应商

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Clozaril is a registered trademark of Sandoz, Inc.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

pictograms

GHS02,GHS06,GHS08

signalword

Danger

hcodes

H225,H301 + H311 + H331,H370

pcodes

P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

存储类别

3 - Flammable liquids

wgk

WGK 1

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

法规信息

危险化学品

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Gastrointestinal hypomotility: an under-recognised life-threatening adverse effect of clozapine.

R J Flanagan et al.

Forensic science international, 206(1-3), e31-e36 (2010-08-20)

To highlight some problems that may occur when investigating clozapine-associated deaths including (i) that death may be related to gastrointestinal hypomotility and (ii) that post-mortem blood clozapine and norclozapine concentrations may not reflect ante-mortem concentrations. A 41-year-old male died 40

Pharmacology of N-desmethylclozapine.

Jelveh Lameh et al.

Pharmacology & therapeutics, 115(2), 223-231 (2007-06-23)

Currently available treatments for schizophrenia have limited efficacy and are generally poorly tolerated. However, among these antipsychotic agents, clozapine stands apart in having generally superior motoric tolerability and efficacy. One intriguing possibility, based on clinical correlations, receptor activity profiles and

Clozapine-induced salivation: interaction with N-desmethylclozapine and amisulpride in an experimental rat model.

Tania Godoy et al.

European journal of oral sciences, 119(4), 275-281 (2011-07-06)

Many drugs (e.g. amisulpride) have been used to treat troublesome clozapine-induced salivation; however, varying success has been achieved in this respect, probably because, until recently, the salivatory action of clozapine has been largely unexplained. In the rat, clozapine and its

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全球贸易项目编号

货号	GTIN
D-048-1ML	04061833553930