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C-046

Supelco

大麻酚标准液 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

经验公式（希尔记法）:
C21H26O2
CAS号:
521-35-7
分子量:
310.43
EC 号:
200-659-6
MDL编号:
MFCD00056774
UNSPSC代码:
41116107
PubChem化学物质编号:
329774794
NACRES:
NA.24

等级

certified reference material

质量水平

300

形式

liquid

特点

SNAP-N-SPIKE®, SNAP-N-SHOOT®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

浓度

1.0 mg/mL in methanol

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

cannabis testing
cannabis testing

格式

single component solution

储存温度

−20°C

SMILES字符串

CCCCCc1cc(O)c-2c(OC(C)(C)c3ccc(C)cc-23)c1

InChI

1S/C21H26O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h9-13,22H,5-8H2,1-4H3

InChI key

VBGLYOIFKLUMQG-UHFFFAOYSA-N

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相关类别

一般描述

这种认证的峰值溶液® 适用于通过 HPLC、GC/MS 或 LC-MS/MS 进行大麻酚测试，从而用于法医分析、临床毒理学、尿液药物测试和大麻效力或杂质分析测试等应用。

大麻酚是一种植物大麻素，属于 C21 萜类化合物。它存在于大麻植物中，也是 Δ9-THC（大麻的主要精神活性成分）的代谢产物。大麻酚还是暴露于空气和光线下四氢大麻酚降解的主要产物。

应用

该认证标准物质（CRM）还可作如下用途：
  • 使用反相高效液相色谱（RP-HPLC）结合二极管阵列检测器（DAD）估算油基质中放入 4 种大麻素
  • 根据国际药品注册协调会议（ICH）分析方法验证三方指南，通过 HPLC-UV 方法对不同大麻品种的生物质和提取物中的 11 种大麻素进行同步分析
  • 使用反相高压液相色谱（RP-HPLC）结合 UV 检测器测定 8 种大麻样品和 12 种法医大麻样品中的 8 种大麻素
  • 采用高效液相色谱法（HPLC）结合 UV 检测分析大麻干花中 9 种大麻素的含量
  • 开发并验证一种超高效液相色谱（UHPLC）方法，结合光电二极管阵列和质谱检测器测定各种大麻样品中的 11 种大麻素
  • 根据 AOAC 和 ASTM 大麻和大麻基质指南，通过 LC-MS/MS 在固相萃取后对大麻和大麻样品中的 17 种大麻素进行定量分析

特点和优势

  • 完全符合 ISO/IEC 17025 和 ISO 17034 认证
  • 附综合分析证书（CoA），包括稳定性、均匀性、浓度准确性、不确定性和可追溯性数据
  • 通过实时稳定性研究严格测试，以确保准确性和保质期
  • 使用合格的精密天平进行重量准备，以确保最小不确定性
  • 氩气环境下火焰密封，装入安瓿以便长期保存
  • 提供方便的 DEA 豁免格式，以提高实验室效率

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

靶器官

Eyes,Central nervous system

WGK

WGK 2

闪点(°F)

49.5 °F

闪点(°C)

9.7 °C

法规信息

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Satoshi Yamaori et al.
Biochemical pharmacology, 79(11), 1691-1698 (2010-02-02)
Inhibitory effects of Delta(9)-tetrahydrocannabinol (Delta(9)-THC), cannabidiol (CBD), and cannabinol (CBN), the three major constituents in marijuana, on catalytic activities of human cytochrome P450 (CYP) 1 enzymes were investigated. These cannabinoids inhibited 7-ethoxyresorufin O-deethylase activity of recombinant CYP1A1, CYP1A2, and CYP1B1
Spyros P Nikas et al.
Journal of medicinal chemistry, 53(19), 6996-7010 (2010-10-12)
In pursuit of a more detailed understanding of the structural requirements for the key side chain cannabinoid pharmacophore, we have extended our SAR to cover a variety of conformationally modified side chains within the 9-keto and 9-hydroxyl tricyclic structures. Of
Dayong Lee et al.
Clinical chemistry, 57(8), 1127-1136 (2011-06-17)
Oral fluid (OF) is an accepted alternative biological matrix for drug treatment, workplace, and DUID (driving under the influence of drugs) investigations, but establishing the cannabinoid OF detection window and concentration cutoff criteria are important. Cannabinoid concentrations were quantified in
Michelle L Holland et al.
European journal of pharmacology, 591(1-3), 128-131 (2008-07-16)
The ATP-binding cassette (ABC) transporter ABCC1, or multidrug resistance-related protein 1 (MRP1) is implicated in Phase II metabolism and multidrug resistance as it effluxes substrate anticancer drugs. As cannabinoids inhibit two related ABC transporters, P-glycoprotein and ABCG2, here we examined
F Van der Kooy et al.
Inhalation toxicology, 21(2), 87-90 (2008-10-16)
Medicinal cannabis has attracted a lot of attention in recent times. Various forms of administration are used, of which smoking is very common but the least desirable. Smoking cannabis generates a large amount of unwanted side products, of which carcinogenic
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